Evidence map›Paper›PMID 41278602›Full record

ArticleAmerican journal of cardiovascular disease2025

Effect of sivelestat on postoperative outcomes in patients with acute type A aortic dissection and hypoxemia: a retrospective analysis.

Yong Lei, Guiying Zhu, Peidong Li, Ziao Lu, Kanglin Xu, Junning Liu

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Article in American journal of cardiovascular disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Yong LeiDepartment of Cardiovascular Surgery, Beijing Anzhen Nanchong Hospital of Capital Medical University and Nanchong Central Hospital, The Second Clinical Medical College of North Sichuan Medical College Nanchong 637000, Sichuan, China.
Guiying ZhuDepartment of Cardiovascular Surgery, Beijing Anzhen Nanchong Hospital of Capital Medical University and Nanchong Central Hospital, The Second Clinical Medical College of North Sichuan Medical College Nanchong 637000, Sichuan, China.
Peidong LiDepartment of Cardiovascular Surgery, Beijing Anzhen Nanchong Hospital of Capital Medical University and Nanchong Central Hospital, The Second Clinical Medical College of North Sichuan Medical College Nanchong 637000, Sichuan, China.
Ziao LuDepartment of Cardiovascular Surgery, Beijing Anzhen Nanchong Hospital of Capital Medical University and Nanchong Central Hospital, The Second Clinical Medical College of North Sichuan Medical College Nanchong 637000, Sichuan, China.
Kanglin XuDepartment of Cardiovascular Surgery, Beijing Anzhen Nanchong Hospital of Capital Medical University and Nanchong Central Hospital, The Second Clinical Medical College of North Sichuan Medical College Nanchong 637000, Sichuan, China.
Junning LiuDepartment of Cardiovascular Surgery, Beijing Anzhen Nanchong Hospital of Capital Medical University and Nanchong Central Hospital, The Second Clinical Medical College of North Sichuan Medical College Nanchong 637000, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPreoperative hypoxemia in patients with acute type A aortic dissection (ATAAD) increases the risk of Postoperative pulmonary complications (PPCs). Sivelestat, which is used for acute lung injury has not been extensively studied in ATAAD patients who develop preoperative hypoxemia. This study first aims to evaluate the impact of sivelestat on the duration of postoperative mechanical ventilation and the length of stay in the Intensive Care Unit (ICU) for patients with ATAAD complicated by hypoxemia. Secondly, we investigate the effects of sodium sivelestat on the oxygenation index (OI, PaO

methodsIn this retrospective study, 143 patients diagnosed with ATAAD undergoing total aortic arch replacement with stent grafting (Sun's) at our hospital (2021-2024) were grouped into sivelestat and non-sivelestat groups. We obtained and compared patient data including demographics, hospitalization, ventilation, and perioperative biomarkers.

resultsIn total, 79 patients (55.2%) experienced preoperative hypoxemia based on the inclusion criteria. Eventually, 65 patients were enrolled in the study after excluding 14 patients. The postoperative PaO

conclusionIn summary, patients with ATAAD and preoperative hypoxemia have lower postoperative PaO

Indexed as

acute type A aortic dissectioneffecthypoxemiaoxygenation indexSivelestat

Identifiers

PMID41278602
PMCPMC12629884

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