Evidence map›Paper›PMID 41278541›Full record

ArticleNAR genomics and bioinformatics2025

MeTAline: enabling reproducible and scalable metagenomic analyses.

Olfat Khannous-Lleiffe, Diego Fuentes-Palacios, Dániel Májer, Toni Gabaldón

Abstract read
In one paragraph

Article in NAR genomics and bioinformatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Olfat Khannous-LleiffeBarcelona Supercomputing Centre (BSC-CNS), Plaça Eusebi Güell, 1-3, Barcelona 08034, Spain.
Diego Fuentes-PalaciosBarcelona Supercomputing Centre (BSC-CNS), Plaça Eusebi Güell, 1-3, Barcelona 08034, Spain.
Dániel MájerBarcelona Supercomputing Centre (BSC-CNS), Plaça Eusebi Güell, 1-3, Barcelona 08034, Spain.
Toni GabaldónBarcelona Supercomputing Centre (BSC-CNS), Plaça Eusebi Güell, 1-3, Barcelona 08034, Spain.ORCID https://orcid.org/0000-0003-0019-1735

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The taxonomic and functional characterization of microbial communities inhabiting a given niche can elucidate associations between the microbiota and relevant variables, including health and disease. As compared to metabarcoding, shotgun metagenomic sequencing, which analyzes all DNA present in a sample, offers superior taxonomic resolution and additionally enables the inference of functional capabilities encoded within the microbial community of interest. However, this approach requires the use of diverse computational tools and substantial computational resources. Here, we present MeTAline, a bioinformatics pipeline for the analysis of shotgun metagenomics data. Implemented in Snakemake, MeTAline provides an efficient and reproducible workflow encompassing read trimming and filtering, host read removal, taxonomic classification via both

Indexed as

MetagenomicsSoftwareComputational BiologyMetagenomeMicrobiotaReproducibility of Results

Identifiers

PMID41278541
PMCPMC12639245

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.