ArticleWorld journal of diabetes2025
RRM2 attenuates the renal tubular ferroptosis in diabetic kidney disease through PI3K/Akt/Nrf2 pathway.
Article in World journal of diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- RRM2 attenuates renal tubular ferroptosis in diabetic kidney diseaseWorld journal of diabetes · 2026Article
- Cell-state- and compartment-dependent PI3K/Akt redox signaling in chronic kidney disease: mechanisms and translational implications.Frontiers in pharmacology · 2026Review
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Authors and funding
3 authors.
Funding
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Abstract
backgroundType 2 diabetes mellitus (T2DM) is associated with significant metabolic and renal complications, including diabetic nephropathy (DN).
aimTo investigate the role of ribonucleotide reductase regulatory subunit M2 (RRM2) in T2DM and its potential involvement in renal injury through oxidative stress, apoptosis, and ferroptosis.
methodsA cross-sectional study was conducted, comprising 194 patients with T2DM and 120 healthy controls at our hospital between January 2022 and December 2023. The data were analyzed to ascertain the correlation between RRM2 levels and DN onset in patients with T2DM. The apoptosis rate, reactive oxygen species (ROS) levels, oxidative stress, cystine uptake, and ferrous ion (Fe
resultsSerum RRM2 levels were significantly higher in T2DM patients than in controls (
conclusionThese findings suggest that RRM2 plays a crucial protective role against diabetic renal injury by mitigating oxidative stress, apoptosis, and ferroptosis
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