Evidence map›Paper›PMID 41278377›Full record

ReviewDigital health

The double-edged algorithm: A rapid review exploring the trustworthy and responsible use of generative AI in public health.

Melissa MacKay, Anjali Kukan, Jennifer E McWhirter

Abstract readReview
In one paragraph

Review in Digital health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Melissa MacKayDepartment of Population Medicine, University of Guelph, Guelph, Ontario, Canada.ORCID https://orcid.org/0000-0002-6682-1528
Anjali KukanDepartment of Population Medicine, University of Guelph, Guelph, Ontario, Canada.ORCID https://orcid.org/0009-0005-3905-6364
Jennifer E McWhirterDepartment of Population Medicine, University of Guelph, Guelph, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Generative artificial intelligence (genAI) technologies have rapidly evolved, offering potential to strengthen core public health functions such as health communication, surveillance, and emergency preparedness. While genAI may enhance public health outcomes by enabling tailored messaging, helping to combat misinformation, and supporting data-driven decision-making, its integration raises significant concerns about equity, privacy, and trust. Methods: This rapid review explores guiding principles for the trustworthy and responsible use of genAI in public health contexts. Following established rapid review protocols, peer-reviewed and grey literature published since 2014 were identified and analyzed thematically. Results: Ten articles met the inclusion criteria, focusing on genAI applications across various public health settings. Ten themes were generated that describe guiding principles for the trustworthy and responsible use of genAI in public health. The themes emphasize the importance of human oversight, transparency, equity, accountability, and culturally relevant communication. While genAI can be used to support health behavior change, enhance health communication across literacy levels, and promote community engagement, risks such as algorithmic bias, data misuse, and the amplification of health disinformation must be mitigated. Conclusion: Organizational policies must reflect ethical considerations and address current regulatory gaps to help mitigate these risks. Workforce training, interdisciplinary collaboration, and policy development are vital to support responsible and trustworthy implementation. This review provides preliminary insights that can help public health organizations begin to consider guidling principles for policies for guiding genAI adoption and use, emphasizing the importance of human-centered and ethically grounded approaches. Findings also identify future research needs, including the evaluation of genAI tools in diverse public health contexts, assessment of real-world impacts, and exploration of governance frameworks. This review offers an initial foundation for public health organizations to consider potential applications of genAI and develop policies that support its responsible and trustworthy use.

Indexed as

equityethicsGenerative artificial intelligencepublic healthtrust

Identifiers

PMID41278377
PMCPMC12638740

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.