Evidence map›Paper›PMID 41278362›Full record

ArticleKidney international reports2025

Frailty Impact on Kidney Transplantation in Older People.

Amarpreet K Thind, Michelle Willicombe, Frank J M F Dor, Lina Johansson, Nicola Thomas, Annabel Rule, Dawn Goodall, Shuli Levy, Sarah Brice, David Ospalla and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Amarpreet K ThindDepartment of Immunology and Inflammation, Centre for Inflammatory Disease, Imperial College London, London, UK.
Michelle WillicombeDepartment of Immunology and Inflammation, Centre for Inflammatory Disease, Imperial College London, London, UK.
Frank J M F DorDivision of Hepatopancreatobilliary and Transplant Surgery, Erasmus MC Transplant Institute, Rotterdam, The Netherlands.
Lina JohanssonImperial College Renal and Transplant Centre, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK.
Nicola ThomasCollege of Health and Life Sciences, London South Bank University, London, UK.
Annabel RuleImperial College Renal and Transplant Centre, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK.
Dawn GoodallImperial College Renal and Transplant Centre, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK.
Shuli LevyImperial College Renal and Transplant Centre, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK.
Sarah BriceImperial College Renal and Transplant Centre, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK.
David OspallaImperial College Healthcare NHS Trust, London, UK.
David WellstedThe Centre for Health Services and Clinical Research, The University of Hertfordshire, Hatfield, Hertfordshire, UK.
Edwina A BrownDepartment of Immunology and Inflammation, Centre for Inflammatory Disease, Imperial College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Kidney transplantation (KT) is increasing in older people. This cohort are vulnerable to frailty, which affects KT outcomes. This study investigated the impact of frailty on quality of life (QoL) and clinical outcomes in older KT candidates and recipients, improving understanding in this population specifically. Methods: KT in Older People (KTOP): Impact of Frailty on Outcomes was a prospective, single-center, longitudinal, observational study. Older people (aged ≥ 60 years) listed for KT were recruited. Frailty was assessed using the Edmonton Frail Scale (EFS). Patient-reported outcomes (PROs) were evaluated using validated questionnaires. Waitlist and KT clinical outcomes were recorded. Descriptive, comparative, and mixed-effect analyses were used to determine PRO and clinical outcome variation by frailty. Results: Two hundred ten participants were recruited, of which 120 were transplanted. At recruitment, 17.2% were frail and 19.4% were vulnerable. Frailty was associated with poorer PROs after KT across all questionnaires. Vulnerable/frail recipients experienced worsening symptom burden, mental QoL, and depression. Nonfrail recipients experienced early physical and mental QoL declines. Both groups reported improved treatment satisfaction and illness intrusiveness. Delayed graft function, 12-month graft function, and KT length-of-stay (LoS) were poorer in vulnerable/frail recipients. On the waitlist, nonfrail participants reported stable PROs, whereas vulnerable/frail participants experienced fluctuations, more infection events, and longer suspensions. Conclusion: The KTOP study provides a detailed, holistic, and longitudinal description of frailty's influence throughout the KT journey in older people. These findings are crucial to enabling more accurate discussions, better shared decision-making, and targeted interventions and clearer goals of KT to be determined.

Indexed as

dialysisfrailtyquality of lifetransplantation

Identifiers

PMID41278362
PMCPMC12640073

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.