Evidence map›Paper›PMID 41278210›Full record

ArticleFrontiers in cell and developmental biology2025

Melk facilitates pulmonary artery smooth muscle cell proliferation and migration in pulmonary hypertension via modulation of YAP/TAZ signaling.

Qiang Yang, Peisheng Chen, Xiaoxia He, Jingting Jian, Miaomiao He, Tianxiao Lin, Shaoqiang Zheng, Degang Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qiang Yang *Department of Thoracic Surgery, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, China.
Peisheng Chen *Department of Gastroenterology, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, China.
Xiaoxia HeDepartment of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jingting JianDepartment of Thoracic Surgery, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, China.
Miaomiao HeDepartment of Thoracic Surgery, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, China.
Tianxiao LinDepartment of Cardiovascular Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Shaoqiang ZhengDepartment of Respiratory Medicine, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, China.
Degang LiuDepartment of Thoracic Surgery, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary arterial hypertension (PAH) is characterized by progressive pulmonary arteriolar constriction and remodeling, leading to elevated vascular resistance and right heart failure. Aberrant proliferation, migration, and phenotypic switching of pulmonary artery smooth muscle cells (PASMCs) are central to this process. Maternal embryonic leucine zipper kinase (MELK), a serine/threonine kinase of the AMPK family, is known to regulate cell cycle and tumorigenesis, but its role in PAH remains unclear. MELK expression was elevated in PASMCs from patients with PAH, in PDGF-BB-stimulated human pulmonary artery smooth muscle cells (HPASMCs), and in PASMCs of Su/H mouse lungs, indicating conserved upregulation across human and experimental models.

Indexed as

cell proliferationhippo-yap/taz signalingmaternal embryonic leucine zipper kinaseMELK inhibitorOTS167pulmonary arterial hypertensionpulmonary artery smooth muscle cells

Identifiers

PMID41278210
PMCPMC12634561

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.