Evidence map›Paper›PMID 41278209›Full record

ArticleFrontiers in cell and developmental biology2025

Non-invasive imaging biomarkers of cellular injury and proliferation in nasopharyngeal carcinoma: insights from multiparametric MRI.

Changjiang Zhao, Lisi Xie, Mengxi He, Xiong Xiong, Chengxin Yu, Yang Liu

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Changjiang Zhao *Department of Radiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People's Hospital, Yichang, Hubei, China.
Lisi Xie *Department of Nuclear Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Mengxi HeDepartment of Pathology, Yichang Central People's Hospital and The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, China.
Xiong XiongDepartment of Radiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People's Hospital, Yichang, Hubei, China.
Chengxin YuDepartment of Radiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People's Hospital, Yichang, Hubei, China.
Yang LiuDepartment of Oncology, Yichang Central People's Hospital and The First College of Clinical Medical Science, China Three Gorges University, Yichang, Hubei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Early identification of therapeutic response and tumor proliferative status is essential in nasopharyngeal carcinoma (NPC). Multiparametric MRI-combining IVIM and DCE-provides quantitative biomarkers reflecting tissue diffusion, perfusion, and vascular permeability. We evaluated whether pre-treatment IVIM- and DCE-derived parameters predict short-term response to induction chemotherapy plus concurrent chemoradiotherapy and whether they correlate with tumor proliferation (Ki-67). Methods: In this prospective study (n = 48; January 2021-January 2023), IVIM parameters (D, D*, f) and DCE parameters (K Results: Pre-treatment D was lower in the CR group (0.82 ± 0.12 vs. 0.92 ± 0.11 ×10 Conclusion: Multiparametric MRI can noninvasively predict short-term response and reflect proliferative status in NPC. Integrating IVIM-derived D with DCE-derived K

Indexed as

cellular injurydynamic contrast-enhanced MRI (DCE-MRI)intravoxel incoherent motion (IVIM)Ki-67nasopharyngeal carcinomaproliferation biomarker

Identifiers

PMID41278209
PMCPMC12634575

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.