ArticleFrontiers in neuroscience2025
Revealing cerebrospinal fluid biomarkers in Parkinson's disease dementia based on iTRAQ proteomics research.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Parkinson's disease dementia (PDD) imposes a significant burden on patients and healthcare systems but currently lacks specific biomarkers. This study aimed to identify novel cerebrospinal fluid (CSF) biomarkers for PDD using proteomics and to explore their functional significance. Methods: Employing iTRAQ-based quantitative proteomics, we analyzed CSF from 73 participants included 34 PD patients, 14 PDD patients and and 25 healthy Controls (HCs). Bioinformatics analysis identified 44 differentially expressed proteins in PDD compared to PD (33 upregulated, 11 downregulated). Subsequent validation by ELISA confirmed a significant decrease in Insulin-like Growth Factor Binding Protein 3 (IGFBP3) concentration in PDD CSF compared to PD, while other candidates (NXPH1, LRRN1, HPRT1) showed no significant differences. Results: These findings suggest that decreased CSF IGFBP3 is a potential biomarker for PDD. Furthermore, IGFBP3 exerts neuroprotective effects against MPP Conclusion: IGFBP3 warrants further investigation as a diagnostic biomarker and therapeutic target for PDD, necessitating future validation in larger cohorts and
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