ArticleWorld journal of gastroenterology2025
Clinical predictors of multidrug-resistant Gram-negative pyogenic liver abscess and nomogram construction: A retrospective analysis.
Article in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- Clinical characteristics and etiological analysis in liver abscess: a retrospective study.Frontiers in cellular and infection microbiology · 2026Article
- A rare case report of pyogenic hepatic abscess secondary to sigmoid diverticulitis.SAGE open medical case reports · 2026Article
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Authors and funding
12 authors.
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Abstract
backgroundIn recent years, there has been a significant increase in pyogenic liver abscesses (PLAs) caused by multidrug-resistant (MDR) Gram-negative bacteria (GNB), predominantly
aimTo clarify the clinical characteristics and risk factors associated with MDR-GNB-related PLAs, develop a predictive nomogram for personalized risk assessment, and enhance the timeliness of empirical antibiotic selection.
methodsBased on the antibiotic susceptibility profiles, enrolled patients were divided into two groups: A MDR group comprising 105 individuals and a non-resistant group comprising 163 individuals. A systematic collection of demographic characteristics, laboratory findings, and prognostic indicators was performed. A predictive nomogram was established using multivariate stepwise regression modeling. Model effectiveness was evaluated by examining its discriminative capability, calibration accuracy, and clinical utility through receiver operating characteristic curves with corresponding area under the curve values, calibration graphs, and decision curve analysis. Continuous data were analyzed using the independent-sample
resultsThis retrospective study analyzed clinical and laboratory data from 268 patients diagnosed with Gram-negative PLA at a major healthcare facility from January 2019 to February 2025. Among these, 105 cases (39%) were associated with MDR-GNB, primarily
conclusionThe results imply that being aged over 60, diabetes, malignant tumor, lower C-reactive protein levels, and higher prothrombin time levels can accurately forecast MDR-GNB infections in PLAs, highlighting the importance of early screening to enable more targeted antibiotic treatments. However, as this was a single-center study without external validation, the generalizability of our model remains limited. Future multicenter, multi-ethnic prospective studies are needed to validate and extend these findings.
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