ArticleWorld journal of gastroenterology2025
Thymosin β4 released by mast cells under stress conditions impairs intestinal epithelial barrier
Article in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMast cells (MCs) under stress conditions contribute to the development of irritable bowel syndrome (IBS), yet their precise mechanisms in IBS remain unclear.
aimTo investigate the role of MC-derived thymosin β4 (Tβ4) in stress-induced intestinal barrier dysfunction.
methodsThe colonic mucus Tβ4 levels in IBS patients were determined and their effects on the epithelial barrier were assessed
resultsWe demonstrated that high levels of Tβ4 in IBS mucus and intestinal MCs mediate stress-associated disruptive changes to the epithelial barrier. Moreover, Tβ4 treatment of wild-type or MC-deficient
conclusionCollectively, these results suggest that Tβ4, which is abundant in IBS mucus and the secretome of MCs, plays a crucial role in the pathogenesis of IBS
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