Evidence map›Paper›PMID 41278159›Full record

Trial reportWorld journal of gastroenterology2025

Multistrain probiotics alleviate gastrointestinal symptoms during bismuth quadruple therapy for

Wen-Jun Liu, Yue-Ming Zhao, Qing-Qing Xie, Min-Chan Wu, Yun-Feng Pan, Hao-Kun Yan, Xiao-Xi Shan, Wen-Ting Xu, Yang-Ling Liu, Cai-Xia Peng and 2 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in World journal of gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wen-Jun LiuDepartment of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, Changsha 410078, Hunan Province, China.
Yue-Ming ZhaoJin Qiao Biotech Co., Ltd., Huai'an 223001, Jiangsu Province, China.
Qing-Qing XieDepartment of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, Changsha 410078, Hunan Province, China.
Min-Chan WuDepartment of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, Changsha 410078, Hunan Province, China.
Yun-Feng PanDepartment of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, Changsha 410078, Hunan Province, China.
Hao-Kun YanJin Qiao Biotech Co., Ltd., Huai'an 223001, Jiangsu Province, China.
Xiao-Xi ShanDepartment of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, Changsha 410078, Hunan Province, China.
Wen-Ting XuDepartment of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, Changsha 410078, Hunan Province, China.
Yang-Ling LiuDepartment of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, Changsha 410078, Hunan Province, China.
Cai-Xia PengDepartment of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, Changsha 410078, Hunan Province, China.
Xiao-Mei ZhangDepartment of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China.
Qian LinDepartment of Nutrition Science and Food Hygiene, Xiangya School of Public Health, Central South University, Changsha 410078, Hunan Province, China. linqian@csu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBismuth quadruple therapy (BQT) induces troublesome gastrointestinal side effects that reduce adherence and efficacy.

aimTo evaluate multistrain probiotics efficacy for alleviating gastrointestinal symptoms during BQT for

methodsOne hundred seventy-four adults (18-60 years) with confirmed

resultsAfter 8 weeks, GSRS scores (all dimensions and total) decreased significantly compared with those at baseline. ITT analysis showed significantly greater reductions for the intervention

conclusionMultistrain probiotics significantly relieved BQT-associated gastrointestinal symptoms without affecting eradication success.

Indexed as

Anti-Bacterial AgentsBismuthGastrointestinal DiseasesHelicobacter InfectionsProbioticsProton Pump InhibitorsAdolescentAdultDiarrheaDouble-Blind MethodDrug Therapy, CombinationFemaleHelicobacter pyloriHumansMaleMiddle AgedAnti-Bacterial AgentsBismuthProton Pump InhibitorsBismuth quadruple therapyGastrointestinal symptomsHelicobacter pylori infectionMultistrain probioticsRandomised controlled trial

Identifiers

PMID41278159
PMCPMC12635774

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.