ArticleFrontiers in pediatrics2025
Clinical analysis of secondary hemophagocytic syndrome in children in Gansu province.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aims to explore and analyze the various causes, clinical features, and prognostic differences of secondary hemophagocytic syndrome (SHS) in children in Gansu Province, China. Method: This study used a retrospective analysis method, selected 43 children with HLH who were treated in the PICU at the First Hospital of Lanzhou University from January 2019 to January 2025. Based on their primary diseases, the subjects were categorized into groups for VL, EB virus infection, and other infections. The clinical manifestations, laboratory results and clinical outcomes of each group were comprehensively analyzed. Results: The main cause of HLH was infection (35/43 cases), with EB virus infection (15/35 cases) and leishmania (13/35 cases) being the most common. In the leishmania and EB virus infection group, the average of alanine aminotransferase (ALT) levels were 81 U/L and 87 U/L respectively, were higher than other infection group ( Conclusion: Leishmania and EB virus infection are common causes of HLH in Gansu Province. Compared to HLH caused by other factors such as EB virus infection or autoimmune diseases, the prognosis of HLH in children with leishmania infection is relatively better.
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