Evidence map›Paper›PMID 41277894›Full record

ArticleTherapeutic advances in hematology2025

Symptoms of depression and anxiety in patients with transfusion-dependent thalassemia after hematopoietic stem cell transplantation: a single-center study.

Xiao Liang, Yumei Huang, Gaohui Yang, Lingling Shi, Lianjin Liu, Hongwen Xiao, Jian Dai, Zhenbin Wei, Lingyuan Pan, Zhaoping Gan and 7 more

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Article in Therapeutic advances in hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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17 authors.

Xiao LiangDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.ORCID https://orcid.org/0009-0006-7604-903X
Yumei HuangDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Gaohui YangDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Lingling ShiDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Lianjin LiuDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Hongwen XiaoDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.ORCID https://orcid.org/0000-0003-2363-0294
Jian DaiDepartment of Clinical Psychology, Jiangbin Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Zhenbin WeiDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Lingyuan PanDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Zhaoping GanDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yu LinDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yibin YaoDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Ying TangDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Huicheng HuangDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Xuemei ZhouDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yongrong LaiDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, China.ORCID https://orcid.org/0000-0002-0371-1719
Rongrong LiuDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Patients with transfusion-dependent thalassemia frequently experience significant psychological distress, with high rates of anxiety and depression reported. Despite this, the psychological status of thalassemia patients after hematopoietic stem cell transplantation (HSCT) remains less explored. Gaining insights into the symptoms of depression and anxiety in this population is crucial, as it can inform tailored support and improve quality of life. Objectives: This study aimed to assess the prevalence of anxiety and depression in post-HSCT thalassemia patients and to identify potential risk factors. Design: This was a cross-sectional study. Methods: A cross-sectional study involved 170 transfusion-dependent thalassemia patients who underwent HSCT from January 2017 to November 2022. The Hospital Anxiety and Depression Scale (HADS), a self-report questionnaire, was used to evaluate the levels of anxiety and depression. Results: The prevalence of anxiety and depression was 11.2% and 8.8%, respectively. Patients with a history of splenectomy and those with chronic graft-versus-host disease (cGVHD) exhibited significantly higher HADS scores ( Conclusion: The study revealed the psychological burden faced by post-transplant thalassemia patients, particularly those with a history of splenectomy and cGVHD. These findings underscore the need for targeted psychological support and interventions for this vulnerable patient group.

Indexed as

anxietydepressionhematopoietic stem cell transplantationthalassemia

Identifiers

PMID41277894
PMCPMC12639217

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