ArticleBone reports2025
Can transient neonatal osteosclerosis be differentiated from malignant infantile osteopetrosis?
Article in Bone reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Osteosclerosis in infancy requires careful evaluation as it may indicate the presence of osteopetrosis. Osteopetrosis is a rare disorder of high bone density due to impaired osteoclast resorption. Infantile forms of osteopetrosis have neurological and hematopoietic defects. However, some infants may present with a transient neonatal osteosclerosis (TNO) appearance without skeletal consequences. The aim of this case series is to compare TNO with infantile osteopetrosis. Radiographic reports of infants less than 12 months old were searched for the terms osteosclerosis and osteopetrosis from 2006 to 2025 at a single tertiary care children's hospital. Serial radiographs performed clinically were extracted and assessed for resolution and the clinical features described. TNO was identified in 7 infants and osteopetrosis was identified in 6 infants. The children with TNO presented at younger age (median age 6 days) than those with osteopetrosis (median age 73 days). All infants with osteopetrosis had genetic confirmation (TCIRG1
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