Evidence map›Paper›PMID 41277882›Full record

ArticleGut microbes2025

Exploring the role of intelectin-1 in modulating asthma through the gut-bone-lung axis.

Shiyue He, Xinyue Hu, Xiaoxiao Gong, Qiyun Cheng, Sheng Zhu, Ya Chen, Yi Luo, Yiyi Wang, Guoqiang Zhu, Tengfei Wan and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shiyue HeDepartment of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, China.ORCID 0009-0006-8711-4597
Xinyue HuDepartment of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, China.
Xiaoxiao GongDepartment of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, China.
Qiyun ChengDepartment of Pathology, School of Basic Medical Science, Central South University, Changsha, China.
Sheng ZhuDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.
Ya ChenDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.
Yi LuoDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.
Yiyi WangDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.
Guoqiang ZhuDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.
Tengfei WanDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.
Chunyuan ChenDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.
Hui LiDepartment of Respiratory and Critical Care Medicine, The First Hospital of Changsha (The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University), Changsha, China.
Pinhua PanDepartment of Respiratory Medicine, National Key Clinical Specialty, Branch of National Clinical Research Center for Respiratory Disease, Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0001-5883-0531
Hui XieDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.
Zhenxing WangDepartment of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, China.ORCID 0000-0003-1575-1459

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe development of extra-intestinal diseases is often accompanied by disruptions in intestinal microbiota and its metabolites, yet the mechanistic link between the gut microbiota and asthma remains unclear. We investigated whether intelectin-1 (ITLN1) mitigates allergic asthma through the gut‒bone‒lung axis as a regulator of gut microbial homeostasis.

methodsSerum samples from 53 asthmatic patients and 34 healthy subjects were analyzed to assess the association between asthma and ITLN1 levels. Mechanism studies were conducted using a house dust mite (HDM)-induced asthma model in

resultsSerum ITLN1 levels inversely correlated with blood eosinophils in asthmatic patients.

conclusionITLN1 is a promising therapeutic target linking gut microbial metabolism to asthma immune regulation using the gut‒bone‒lung axis.

Indexed as

AsthmaBone and BonesGastrointestinal MicrobiomeLectinsLungAdultAnimalsBacteriaCytokinesDisease Models, AnimalEosinophilsFecesFemaleGPI-Linked ProteinsHumansMaleCytokinesGPI-Linked ProteinsITLN1 protein, humanLectinsasthmabutyrategut–bone–lung axisgut microbiotaIntelectin-1type 2 inflammation

Identifiers

PMID41277882
PMCPMC12645851

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.