Evidence map›Paper›PMID 41277867›Full record

ArticlemBio2026

Mechanistic insights into dual-active liver and blood-stage antiplasmodials.

Mukul Rawat, Nonlawat Boonyalai, Cindy Smidt, Madeline R Luth, Daisy Chen, Andrew Plater, John Post, De Lin, Joel McMillan, Thomas Eadsforth and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Mukul RawatDivision of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, United Kingdom.ORCID 0000-0003-1264-7680
Nonlawat BoonyalaiDivision of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, United Kingdom.
Cindy SmidtWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Madeline R LuthDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.
Daisy ChenDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.
Andrew PlaterDrug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee, United Kingdom.
John PostDrug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee, United Kingdom.
De LinDrug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee, United Kingdom.
Joel McMillanDrug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee, United Kingdom.
Thomas EadsforthDrug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee, United Kingdom.
Sonia Moliner-CubelGlobal Health Medicines R&D, GSK, Severo Ochoa, Tres Cantos, Spain.
Oliver BillkerDepartment of Molecular Biology, Umeå University, Umeå, Sweden.
Julian C RaynerCambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-9835-1014
Fransisco-Javier GamoGlobal Health Medicines R&D, GSK, Severo Ochoa, Tres Cantos, Spain.
Beatriz BaragañaDrug Discovery Unit, Division of Biological Chemistry and Drug Discovery, School of Life Science, University of Dundee, Dundee, United Kingdom.
Elizabeth A WinzelerDepartment of Pediatrics, University of California San Diego, La Jolla, California, USA.
Marcus C S LeeDivision of Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, United Kingdom.ORCID 0000-0002-4973-0915

Funding

Training Program in Basic Clinical GeneticsT32GM008666 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HAMILTON, BRUCE A · 1998 to 2021
$8.6M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
Bill and Melinda Gates Foundation INV-045096Bill and Melinda Gates Foundation INV-071352NIGMS NIH HHS T32 GM008666NIH HHS S10 OD026929Wellcome TrustWellcome Trust 203134/A/16/ZWellcome Trust 206194/Z/17/Z
6 · The paper itself

Abstract

The identification of novel antimalarials with activity against both the liver and blood stages of the parasite lifecycle would have the dual benefit of prophylactic and curative potential. However, one challenge of leveraging chemical hits from phenotypic screens is subsequent target identification. Here, we use

Indexed as

AntimalarialsLiverPlasmodium falciparumDrug ResistanceHumansMutationProtozoan ProteinsAntimalarialsProtozoan Proteinsantimalarial agentsdrug resistance mechanismsmalaria

Identifiers

PMID41277867
PMCPMC12802172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.