Evidence map›Paper›PMID 41277851›Full record

ArticleJournal of bacteriology2025

Inactivation of cAMP receptor protein (MSMEG_6189) increases isoniazid susceptibility in

Narin Kim, Yuna Oh, Jeong-Il Oh

Abstract read
In one paragraph

Article in Journal of bacteriology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Narin Kim *Department of Integrated Biological Science, Pusan National University, Busan, South Korea.
Yuna Oh *Department of Integrated Biological Science, Pusan National University, Busan, South Korea.
Jeong-Il OhDepartment of Integrated Biological Science, Pusan National University, Busan, South Korea.ORCID 0000-0002-9250-2627

Funding

National Research Foundation of Korea NRF-2023R1A2C1002999
6 · The paper itself

Abstract

Isoniazid (INH) is a first-line drug for treating drug-susceptible tuberculosis. The genome of IMPORTANCE: This study revealed that the cAMP receptor protein, Crp1, plays a role in controlling key genes involved in both INH activation (

Indexed as

Antitubercular AgentsBacterial ProteinsCyclic AMP Receptor ProteinIsoniazidMycobacterium smegmatisOxidative PhosphorylationReactive Oxygen SpeciesDrug Resistance, BacterialGene Expression Regulation, BacterialMicrobial Sensitivity TestsAntitubercular AgentsBacterial ProteinsCyclic AMP Receptor ProteinIsoniazidReactive Oxygen SpeciesAhpCcAMP receptor proteinelectron transport chainisoniazidKatGMycobacteriumROS

Identifiers

PMID41277851
PMCPMC12713383

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.