ArticleJournal of virology2025
Cmss1 limits FMDV infection by enhancing antigen presentation and CD8
Yang Wang, Lihong Zhang, Jieru Deng, Linlin Zheng, Zhihua Chen, Zhao Zhang, Han Zhang, Jingjing Pei, Haixue Zheng
Abstract read
In one paragraphArticle in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
Yang Wang *State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.ORCID 0000-0003-0138-5523 Lihong Zhang *State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Jieru Deng *Department of Microbiology and Immunology, The University of Melbourne, at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Linlin ZhengState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Zhihua ChenState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Zhao ZhangState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Han ZhangState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Jingjing PeiState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.ORCID 0000-0002-3979-8991 Haixue ZhengState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.ORCID 0000-0001-6850-1379 Funding
Foundation for Innovation Groups of Basic Research in Gansu Province 24JRRA783 and 23JRRA561Hatch Project of State Key Laboratory of Animal Disease Control and Prevention SKLADCP2023HP02Key Science and Technology Foundation of Gansu Province 22ZD6NA001National Key Research and Development Program of China 2021YFD1800300National Natural Science Foundation of China 32330107Natural Science Foundation of Gansu Province 24JRRA013Support Program for Longyuan Youth and Fundamental Research Funds for the Universities of Gansu Province 2024QNTD18
6 · The paper itselfAbstract
The foot and mouth disease virus (FMDV) poses a heavy burden on the global swine industry, underscoring the urgent need for long-term protective vaccines to control FMDV infection. Dendritic cells (DCs) are critical in activating innate immune cells and initiating adaptive immune responses. However, the role of DCs in FMDV infection remains poorly understood. In this study, we developed a mouse model lacking the type I interferon receptor for infection, followed by single-cell RNA sequencing to generate a high-resolution map of DCs in the spleens of FMDV-infected mice. Next, we established an evaluation system to investigate the antigen-presenting capacities of gene-edited DCs and mice. The results reveal that FMDV infection alters the proportions of DC subsets and significantly suppresses antigen processing and presentation. Additionally, we identified Cmss1 as a novel host factor that antagonizes the inhibition of the antigen-presenting process caused by FMDV infection, thereby limiting FMDV pathogenicity in mice. These findings provide valuable insights into potential antiviral strategies against FMDV infection.IMPORTANCEIn this study, we first developed C57BL/6 mice lacking the type I interferon receptor as an infectious model, which was subjected to single-cell RNA sequencing analysis of DC features in response to FMDV infection. We identified VP41
Indexed as
Antigen PresentationCD8-Positive T-LymphocytesFoot-and-Mouth DiseaseFoot-and-Mouth Disease VirusAnimalsDendritic CellsDisease Models, AnimalMiceMice, Inbred C57BLMice, KnockoutReceptor, Interferon alpha-betaReceptor, Interferon alpha-betaantigen presentationCmss1dendritic cellsFMDVsingle-cell RNA sequencing
Identifiers
PMID41277842
PMCPMC12724260
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