Evidence map›Paper›PMID 41277681›Full record

SynthesisBrain and behavior2025

The Global Impact of COVID-19 Control Measures on People With Dementia Living at Home and Their Carers: A Systematic Review of Quantitative and Qualitative Research Across 27 Countries.

Yaohua Chen, Tatyana Mollayeva, Rachael Fitzpatrick, Thaisa Tylinski Sant'Ana, Francesca Farina, Dorota Swiatek, Kelli Sopidou, Evelyn Tabilo, Marta Betka, Iracema Leroi and 3 more

Abstract readSystematic Review
In one paragraph

Synthesis in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yaohua ChenDepartment of Geriatrics, Univeristy of Lille, CHU Lille, U1172, LilNCog, Lille, France.ORCID https://orcid.org/0000-0003-1778-1790
Tatyana MollayevaGlobal Brain Health Institute, Trinity College Dublin, University of California San Francisco, Dublin, San Francisco.ORCID https://orcid.org/0000-0002-2787-1848
Rachael FitzpatrickDepartment of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, Ireland.ORCID https://orcid.org/0000-0002-8795-7627
Thaisa Tylinski Sant'AnaKITE-Toronto Rehab-University Health Network, Toronto, Ontario, Canada.ORCID https://orcid.org/0009-0006-8889-2112
Francesca FarinaGlobal Brain Health Institute, Trinity College Dublin, University of California San Francisco, Dublin, San Francisco.ORCID https://orcid.org/0000-0002-4410-4368
Dorota SwiatekRegional Specialist Hospital in Wrocław Research and Development Center, Wroclaw, Poland.ORCID https://orcid.org/0000-0003-4787-4269
Kelli SopidouNeurosciences and Neurodegenerative diseases, Medical School, Faculty of HealthSciences, Aristotle University, Athens, Greece.ORCID https://orcid.org/0009-0005-4722-2174
Evelyn TabiloGerosciences Center for Brain Health and Metabolism (GERO), Santiago, Chile.
Marta BetkaMazowiecki Szpital Bródnowski, Warsaw Medical University, Warsaw, Poland.ORCID https://orcid.org/0000-0002-9308-8915
Iracema LeroiGlobal Brain Health Institute, Trinity College Dublin, University of California San Francisco, Dublin, San Francisco.ORCID https://orcid.org/0000-0003-1822-3643
Tomas LeonGlobal Brain Health Institute, Trinity College Dublin, University of California San Francisco, Dublin, San Francisco.ORCID https://orcid.org/0000-0003-3595-0586
Geeske PeetersGlobal Brain Health Institute, Trinity College Dublin, University of California San Francisco, Dublin, San Francisco.ORCID https://orcid.org/0000-0003-4460-7026
STRAP consortium

Funding

CIHREU Joint Programme - Neurodegenerative Disease Research
6 · The paper itself

Abstract

backgroundCOVID-19 control measures have had a unique impact on people with dementia (PWD) and their carers living at home. Yet, uncertainty exists regarding the global impact of such measures and whether differences exist between countries and global regions. We aimed to synthesize evidence on this topic.

methodsWe searched Medline, PsycINFO, EMBASE, Web of Science, CINAHL, Latin American and Caribbean Health Literature (LILACS), Scientific Electronic Library Online (SciELO), and EM Premium from the start of the pandemic to July 2022. At least two researchers independently screened citations and performed quality assessment following recommended criteria for critical appraisal according to study methodology. We analyzed data by country and region and synthesized results descriptively.

resultsSixty-nine studies met inclusion criteria (74% quantitative and 26% qualitative; 22% included PWD, 44% carers of PWD, and 4% dyads), with a total of 209,738 participants. Most studies were conducted in Europe (59%), followed by Asia and North America (15% each), South America (7%), and Oceania (1%). Two studies presented data from multiple regions (3%). The quality of the studies varied, with the majority (62%) being of moderate quality. Across the study populations and global regions, COVID-19 control measures had implications for PWD and carers' access to health services, physical and mental health and daily routine, cognition, behavior, with accompanying social and economic costs. The impact on mental health for PWD and on loneliness and well-being for carers were the two most frequently studied outcomes.

conclusionPeople with dementia and their carers represent a heterogeneous group of people across countries and communities; despite that, the impacts of COVID-19 control measures on PWD and their carers were broadly consistent across regions. Our evidence synthesis highlights the critical need for decision-makers to account for the needs of PWD and their carers when designing and implementing public health measures. OTHER: This work was funded by the JPND Call for Expert Working Groups: The Impact of COVID-19 on Neurodegenerative Diseases in partnership with the CIHR-Institute of Aging and the Public Health Agency (CIHR #02342-000). PROSPERO CRD42024554701.

Indexed as

CaregiversCOVID-19DementiaGlobal HealthHumansQualitative ResearchSARS-CoV-2carersdementiahealthcare accessmental healthprognosisSARS‐CoV‐2

Identifiers

PMID41277681
PMCPMC12641281

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.