Observational studyThe Journal of hand surgery, European volume2026
Combined nerve and tendon transfer (CNaTT) for grasp and release function in patients with tetraplegia: a matched prospective pilot study.
Observational study in The Journal of hand surgery, European volume, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionTraditional single-stage tendon transfer procedures in patients with tetraplegia are designed to restore active pinch and grasp function. However, digital extension is usually achieved by wrist tenodesis. More recently, nerve transfer has allowed potential restoration of digital extension. This matched observational pilot study compares clinical outcomes after traditional tendon transfers vs. a study group using two-stage using combined nerve and tendon transfer.
methodsEighteen patients in the traditional tendon transfer control group and 18 patients in the combined nerve and tendon transfer group using a supinator branches to posterior interosseous nerve (S-PIN) transfer were compared. Primary outcomes include hand opening capacity, using the cylinder test. Secondary outcomes include muscle strength, first web space opening, grip and pinch strength, grasp and release ability, and activity performance.
resultsAnalyses indicated that adding a nerve transfer allowed more patients to achieve normal one-handed hand opening, although this difference was not statistically significant. Secondary outcomes revealed superior grasp and release ability and pinch opening in the study group; however, there were no notable differences in grip strength and activity performance between the groups.
conclusionsAdding a S-PIN nerve transfer appears to enhance grasp function in the tetraplegic limb when combined with established tendon transfer techniques. For individuals with tetraplegia, the capacity to use single hand grips is particularly significant, as it allows the other arm to stabilize and compensate for limited core balance. More participants with a longer follow-up are needed to fully demonstrate the superiority of combined nerve and tendon procedures. LEVEL OF EVIDENCE: III.
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