ArticleAnnals of medicine2025
Bronchoscopic management of airway fistulas: a clinical analysis of 45 cases with integrated bioinformatic analysis.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Etiological profile and prognostic factors of airway fistula: a retrospective study.Journal of thoracic disease · 2026Article
- The role of thoracoplasty in modern thoracic surgery: a narrative review with three illustrative cases.Journal of thoracic disease · 2026Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAirway fistula represents a complex clinical condition where the optimal bronchoscopic management remains controversial. This study aims to evaluate clinical characteristics, bronchoscopic treatment efficacy, and prognostic factors.
methodsThis retrospective study analysed 45 patients with fistulas who underwent a total of 56 bronchoscopic intervention sessions over the past seven years. The fistulas were categorized and analysed based on their size, clinical features and treatment efficacy, with prognostic factors for healing being evaluated. In parallel, a bioinformatic analysis was initiated with 2075 genes sourced from GeneCards. Following filtration, the top 20 hub genes were identified and subsequently subjected to pathway enrichment analysis to elucidate the underlying mechanisms.
resultsCompared to the non-remission group, the remission group exhibited significantly smaller fistula diameters, higher lymphocyte counts, and lower high-sensitivity C-reactive protein (hsCRP) levels. Prognostic analysis revealed that fistula size and hsCRP level were independent predictors. Small fistulas (≤5 mm) cases solely underwent blocking agent intervention had a significantly higher remission rate. While the others (>5 mm) were mostly managed with stents, endobronchial valves, and cardiac occluders. Bioinformatic analysis of public data identified significant enrichment in the PI3K-AKT signaling pathway and cytokine-cytokine receptor interaction pathway, pinpointing six core genes, including CXCL8, IL1B, IL6, TNF, TGFB1, and IL13.
conclusionsPrioritize bronchoscopic treatment with inflammation control for small fistulas; recommend combined therapies for large fistulas.The PI3K-AKT and cytokine pathways may be involved in healing and represent potential targets for future drug development.
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