Evidence map›Paper›PMID 41277555›Full record

ArticleJCI insight2025

A shift in PKM2 oligomeric state instructs adipocyte inflammatory potential.

Michelle Sma Damen, Pablo C Alarcon, Calvin C Chan, Traci E Stankiewicz, Hak Chung, Keisuke Sawada, Cassidy J Ulanowicz, John Eom, Jarren R Oates, Jennifer L Wayland and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JCI insight, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Michelle Sma DamenDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Pablo C AlarconDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Calvin C ChanDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Traci E StankiewiczDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Hak ChungDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Keisuke SawadaDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Cassidy J UlanowiczDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
John EomDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Jarren R OatesDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Jennifer L WaylandDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Jessica R DollDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Rajib MukherjeeDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Miki Watanabe-ChaillandDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Lindsey Romick-RosendaleDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Sara SzaboDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Michael A HelmrathDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Joan Sanchez-GurmachesDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Maria E Moreno-FernandezDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Senad DivanovicDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Funding

Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Alexander Miethke · 2007 to 2026
$24.4M
PEDIATRIC GASTROENTEROLOGY AND NUTRITION TRAINING GRANTT32DK007727 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Phillip P Minar · 1995 to 2026
$11.3M
Immunopathogenesis of Non-alcoholic Fatty Liver DiseaseR01DK099222 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Senad Divanovic · 2013 to 2026
$5.6M
Pathogenesis and therapeutic targeting of immune disordersT32AI118697 · NIAID · CINCINNATI CHILDRENS HOSP MED CTR · PI HILDEMAN, DAVID A · 2016 to 2020
$683k
Contribution of adipocyte inflammation to parturition timingF30HD117460 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI Jennifer Lynne Wayland · 2025 to 2026
$98k
NIAID NIH HHS T32 AI118697NICHD NIH HHS F30 HD117460NIDDK NIH HHS P30 DK078392NIDDK NIH HHS R01 DK099222NIDDK NIH HHS T32 DK007727
6 · The paper itself

Abstract

Processes that promote white adipocyte inflammatory function remain incompletely defined. Here, we demonstrated that type I interferon-dependent (IFN-I-dependent) skewing of adipocyte glycolysis, nicotinamide adenine dinucleotide (NAD+) utilization, and pyruvate kinase isozyme M2 (PKM2) function may contribute to increased systemic and tissue inflammation and disease severity in obesity. Notably, chemical and/or genetic inhibition of glycolysis, the NAD+ salvage pathway, or PKM2 restricted IFN-I-dependent increase in adipocyte inflammatory cytokine production. Further, genetic or small molecule targeting of PKM2 function in vivo was sufficient to reduce systemic and tissue inflammation and metabolic disease severity in obese mice, in an adipocyte PKM2-dependent manner. Further, white adipose tissue of individuals living with obesity and metabolic disease, compared with metabolically healthy individuals with obesity, showed an increase in expression of inflammatory and metabolic genes, while small molecule targeting of PKM2 function contributed to reduced IFN-I-driven inflammatory cytokine production by primary human adipocytes. Together, our findings invoke the IFN-I/PKM2 axis as a potential target for modulating adipocyte dysregulated inflammation.

Indexed as

AdipocytesCarrier ProteinsInflammationMembrane ProteinsObesityPyruvate KinaseThyroid HormonesAdipose Tissue, WhiteAnimalsCytokinesFemaleGlycolysisHumansInterferon Type IMaleMiceCarrier ProteinsCytokinesInterferon Type IMembrane ProteinsNADPkm protein, mousePyruvate KinaseThyroid Hormone-Binding ProteinsThyroid HormonesAdipose tissueCytokinesImmunologyInflammationMetabolismObesity

Identifiers

PMID41277555
PMCPMC12643483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.