Evidence map›Paper›PMID 41277535›Full record

ArticleStem cells translational medicine2025

Tracking leukemic residuals: dissecting the inverse relationship between CD26+ stem cells and extracellular BCR::ABL1 transcript in Chronic Myeloid Leukemia (CML).

Silvia Mutti, Alessia Cavalleri, Anna Sicuranza, Paola Pacelli, Claudia Ielo, Lucia Paolini, Valentina Mangolini, Alessandro Leoni, Teresa Miracapillo, Camilla Turriziani and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Silvia MuttiUnit of Blood Diseases and Bone Marrow Transplant, Department of Clinical and Experimental Sciences (DSCS), Università di Brescia, ASST Spedali Civili, Brescia 25123, Italy.
Alessia CavalleriUnit of Blood Diseases and Bone Marrow Transplant, Department of Clinical and Experimental Sciences (DSCS), Università di Brescia, ASST Spedali Civili, Brescia 25123, Italy.
Anna SicuranzaAzienda Ospedaliera Universitaria, University of Siena, Siena 53100, Italy.
Paola PacelliAzienda Ospedaliera Universitaria, University of Siena, Siena 53100, Italy.
Claudia IeloUmberto I Policlinico, La Sapienza University, Rome 00161, Italy.
Lucia PaoliniDepartment of Medical and Surgical Specialties, Radiological Sciences and Public Health (DSMC), Università di Brescia, Brescia, 25123, Italy.
Valentina MangoliniDepartment of Molecular and Translational Medicine (DMMT), Università di Brescia, Brescia 25123, Italy.
Alessandro LeoniUnit of Blood Diseases and Bone Marrow Transplant, Department of Clinical and Experimental Sciences (DSCS), Università di Brescia, ASST Spedali Civili, Brescia 25123, Italy.
Teresa MiracapilloAzienda Ospedaliera Universitaria, University of Siena, Siena 53100, Italy.
Camilla TurrizianiAzienda Ospedaliera Universitaria, University of Siena, Siena 53100, Italy.
Elisabetta AbruzzeseHematology, S. Eugenio Hospital , ASLRoma2 00144, Italy.
Mirko FarinaUnit of Blood Diseases and Bone Marrow Transplant, Department of Clinical and Experimental Sciences (DSCS), Università di Brescia, ASST Spedali Civili, Brescia 25123, Italy.
Annalisa RadeghieriDepartment of Molecular and Translational Medicine (DMMT), Università di Brescia, Brescia 25123, Italy.
Michele MalagolaUnit of Blood Diseases and Bone Marrow Transplant, Department of Clinical and Experimental Sciences (DSCS), Università di Brescia, ASST Spedali Civili, Brescia 25123, Italy.
Massimo BrecciaUmberto I Policlinico, La Sapienza University, Rome 00161, Italy.
Monica BocchiaAzienda Ospedaliera Universitaria, University of Siena, Siena 53100, Italy.
Domenico RussoUnit of Blood Diseases and Bone Marrow Transplant, Department of Clinical and Experimental Sciences (DSCS), Università di Brescia, ASST Spedali Civili, Brescia 25123, Italy.
Simona BernardiUnit of Blood Diseases and Bone Marrow Transplant, Department of Clinical and Experimental Sciences (DSCS), Università di Brescia, ASST Spedali Civili, Brescia 25123, Italy.ORCID 0000-0002-3494-2624

Funding

European Union-Next Generation EU B93D21010860004
6 · The paper itself

Abstract

Chronic myeloid leukemia (CML) persists due to leukemic stem cells, notably the CD26+ subset. We investigated correlations between circulating CD26+ leukemic stem cells (LSCs) and BCR::ABL1 transcripts in an extracellular vesicle-enriched secretome (EVES) from plasma samples of 44 CML patients. EVES were characterized and BCR::ABL1 quantified via digital PCR. We observed an inverse correlation between CD26+LSC counts and EVES BCR::ABL1 levels, especially in deep molecular responders (DMR). CD26+LSCs were elevated in patients in treatment-free remission (TFR), while EVES BCR::ABL1 levels were higher in those receiving therapy. These findings suggest distinct dynamics between LSC populations and vesicle-mediated transcript release, with potential implications for CML monitoring and prognosis.

Indexed as

Dipeptidyl Peptidase 4Fusion Proteins, bcr-ablLeukemia, Myelogenous, Chronic, BCR-ABL PositiveNeoplastic Stem CellsAdultAgedExtracellular VesiclesFemaleHumansMaleMiddle AgedBCR-ABL1 fusion protein, humanDipeptidyl Peptidase 4DPP4 protein, humanFusion Proteins, bcr-ablBCR::ABL1CD26chronic myeloid leukemiaEVESleukemic stem cells

Identifiers

PMID41277535
PMCPMC12641227

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.