Evidence map›Paper›PMID 41277393›Full record

ArticlePlant biotechnology journal2026

Natural Variation of TaSG-D1-TaWRKY53 Module Regulates Heading Date in Wheat.

Xingyuan Xi, Tong Zhu, Guangxian Cui, Yan Zhou, Baoyue Zhang, Haoran Qi, Hongjiao Jiang, Zhen Qin, Yumei Zhang, Huiru Peng and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant biotechnology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Xingyuan XiFrontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis Utilization (MOE), China Agricultural University, Beijing, China.
Tong ZhuFrontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis Utilization (MOE), China Agricultural University, Beijing, China.
Guangxian CuiFrontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis Utilization (MOE), China Agricultural University, Beijing, China.
Yan ZhouFrontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis Utilization (MOE), China Agricultural University, Beijing, China.
Baoyue ZhangFrontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis Utilization (MOE), China Agricultural University, Beijing, China.
Haoran QiFrontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis Utilization (MOE), China Agricultural University, Beijing, China.
Hongjiao JiangFrontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis Utilization (MOE), China Agricultural University, Beijing, China.
Zhen QinFrontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis Utilization (MOE), China Agricultural University, Beijing, China.
Yumei ZhangQingdao Agricultural University, Qingdao, China.
Huiru PengFrontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis Utilization (MOE), China Agricultural University, Beijing, China.ORCID https://orcid.org/0009-0002-7920-610X
Yingyin YaoFrontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis Utilization (MOE), China Agricultural University, Beijing, China.
Zhaorong HuFrontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis Utilization (MOE), China Agricultural University, Beijing, China.ORCID https://orcid.org/0000-0002-1815-648X
Zhongfu NiFrontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis Utilization (MOE), China Agricultural University, Beijing, China.
Ive De SmetDepartment of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, Belgium.
Qixin SunFrontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis Utilization (MOE), China Agricultural University, Beijing, China.
Mingming XinFrontiers Science Center for Molecular Design Breeding, Key Laboratory of Crop Heterosis Utilization (MOE), China Agricultural University, Beijing, China.

Funding

National Natural Science Foundation of China W2412027Shandong Provincial Key Research and Development Plan 2025LZGC001
6 · The paper itself

Abstract

Heading date is a critical determinant of regional adaptation and yield potential. Here, we identify an E286K substitution in TaSG-D1, encoding an STKc_GSK3 kinase, which delays heading date in wheat. Mechanistically, this substitution strengthens the physical interaction between TaSG-D1 and TaWRKY53 and enhances the phosphorylation of TaWRKY53. Interestingly, the phosphorylation confers increased transcriptional activation of TaWRKY53 to the downstream gene VRN2. We further show that TaWRKY53 has been under artificial selection during Chinese wheat breeding. Modern cultivars frequently carry a premature stop codon in TaWRKY53, resulting in a 34 amino acid truncation relative to local landraces. This truncation eliminates phosphorylation of TaWRKY53 and impairs its transcriptional activity, which reduces VRN2 expression and ultimately accelerates heading. Our findings unveil a TaSG-D1-TaWRKY53 regulatory module controlling heading date and identify key genetic variants underlying wheat adaptation to the double-cropping system in China.

Indexed as

Plant ProteinsTriticumGene Expression Regulation, PlantGenetic VariationPhosphorylationPlant BreedingPlant Proteins

Identifiers

PMID41277393
PMCPMC13140276

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.