ArticlePediatric pulmonology2025
REM-OSA vs NREM-OSA in Children: Separate Clinical Phenotypes or Markers of OSA Severity.
Article in Pediatric pulmonology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- REM-OSA vs NREM-OSA in Children: Separate Clinical Phenotypes or Markers of OSA Severity.Pediatric pulmonology · 2025Article
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5 authors.
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Abstract
introductionObstructive sleep apnea (OSA) occurs predominantly during REM sleep (REM-OSA) compared to NREM sleep (NREM-OSA) in both children and adults. However, it is not clear whether REM-OSA and NREM-OSA are separate clinical phenotypes of OSA or represent 2 ends of OSA severity spectrum.
objectiveWe aimed to compare clinical and polysomnography (PSG) characteristics of REM-OSA versus NREM-OSA in children, and to evaluate the effect of these characteristics on REM-related over NREM-related obstructive AHI ratio (REM-OAHI/NREM-OAHI).
methodsClinical and PSG data of all children diagnosed with moderate to severe OSA by PSG between 2019 and 2024 were collected and analyzed. REM-OSA was defined as REM-OAHI/NREM-OAHI ratio of ≥2. NREM-OSA was defined as REM-OAHI/NREM-OAHI of < 2.
resultsA total of 253 patients (169 male and 84 female) met the inclusion criteria. REM-OSA was identified in 174 (68.7%) patients, and NREM-OSA in 79 (31.2%) patients. There was no significant difference between REM-OSA and NREM OSA groups in gender, BMI, clinical diagnosis, symptoms or oxygenation indices. However, REM-OSA group had lower OAHI and less severe OSA than NREM-OSA group (p = 0.004, p = 0.003, respectively). Regression analysis showed that low OAHI was the only significant predictor of REM-OSA and the only predictor of high REM-AHI/NREM-AHI ratio, respectively (p = 0.001, p = 0.001).
conclusionREM-OSA and NREM-OSA are not likely to be separate clinical phenotypes of OSA but only markers of the disease severity, with NREM-OSA indicating more severe disease.
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