Evidence map›Paper›PMID 41277176›Full record

ArticleSmall methods2025

Superferromagnetic Disk Particles for Magnetic Particle Imaging.

Erik M Mayr, Justin Ackers, Alexander Gogos, Subas Scheibler, Michal Krupinski, Matthias Graeser, Inge K Herrmann, Hans J Hug

Abstract read
In one paragraph

Article in Small methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Erik M MayrNanoparticle Systems Engineering Laboratory, Department of Mechanical and Process Engineering, ETH Zurich, Sonneggstrasse 3, 8092, Zurich, Switzerland.ORCID https://orcid.org/0009-0009-4217-9938
Justin AckersFraunhofer IMTE, Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering, Mönkhofer Weg 239a, 23562, Lübeck, Germany.ORCID https://orcid.org/0000-0003-1049-0528
Alexander GogosNanomaterials in Health Laboratory, Swiss Federal Laboratories for Materials Science and Technology (Empa), Lerchenfeldstrasse 5, 9014, St. Gallen, Switzerland.ORCID https://orcid.org/0000-0001-6233-512X
Subas ScheiblerNanoparticle Systems Engineering Laboratory, Department of Mechanical and Process Engineering, ETH Zurich, Sonneggstrasse 3, 8092, Zurich, Switzerland.ORCID https://orcid.org/0000-0003-0425-0026
Michal KrupinskiInstitute of Nuclear Physics, Polish Academy of Sciences, Radzikowskiego 152, 31-342, Kraków, Poland.ORCID https://orcid.org/0000-0003-2984-2052
Matthias GraeserFraunhofer IMTE, Fraunhofer Research Institution for Individualized and Cell-Based Medical Engineering, Mönkhofer Weg 239a, 23562, Lübeck, Germany.ORCID https://orcid.org/0000-0003-1472-5988
Inge K HerrmannNanoparticle Systems Engineering Laboratory, Department of Mechanical and Process Engineering, ETH Zurich, Sonneggstrasse 3, 8092, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-3018-6796
Hans J HugMagnetic & Functional Thin Films Laboratory, Swiss Federal Laboratories for Materials Science and Technology Empa, Ueberlandstrasse 129, 8600, Dübendorf, Switzerland.ORCID https://orcid.org/0000-0002-1281-4138

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung 181290
6 · The paper itself

Abstract

Magnetic particle imaging (MPI) offers rapid, highly sensitive tracer-based imaging without ionizing radiation, but its clinical translation remains challenged by the limited performance of existing superparamagnetic (SP) tracers. In this work, precisely engineered disk-shaped nanoparticles fabricated from superferromagnetic (SF) discontinuous metal-insulator multilayers (DMIMs) consisting of SP nanoscale metal islands embedded in a nonmagnetic oxidic matrix are introduced. By leveraging inter-island exchange interactions, robust SF behavior is achieved in extended DMIMs, exhibiting exceptionally high susceptibilities and a sharp magnetization switching at fields below 1 mT. When evaluated in MPI experiments, magnetic disk particles (MDP) with a diameter of 1800 nm patterned from the SF DMIMs demonstrate up to a 1.6-fold improvement in spatial resolution and a 2.4-fold increase in sensitivity compared to Perimag tracers, the current gold standard in MPI. System matrix measurements and hybrid MPI reconstructions further highlight the superior imaging characteristics of MDP tracers in complex, clinically relevant geometries. These findings establish SF DMIM disks as a promising next-generation tracer platform for MPI, with the potential to simplify scanner designs and to pave the way for a clinical translation of MPI.

Indexed as

magnetic disk particlesmagnetic nanoparticlesmagnetic particle imagingsuper ferromagnetism

Identifiers

PMID41277176
PMCPMC12716192

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.