Evidence map›Paper›PMID 41277070›Full record

ArticleDrug delivery2025

Neuromodulation with low-intensity pulsed ultrasound (Lipus) combined with curcumin-gold nanoparticles (Cur-AuNPs) in an Alzheimer's disease model.

Laura de Roch Casagrande, Eduarda Behenck Medeiros, Ligia Milanez Venturini, Rubya Pereira Zaccaron, Camila da Costa, João Vitor Silvano Bittencourt, Henrique Borba Modolon, Adrielly Vargas Lidio, Sabrina Arcaro, Josiane Budni and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Laura de Roch CasagrandeFaculty of Sports Science, Ningbo University, Ningbo, China.
Eduarda Behenck MedeirosLaboratory of Experimental Neurology in the Line of Research in Neurodegenerative Diseases of the Postgraduate Program in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Brazil.
Ligia Milanez VenturiniLaboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Brazil.
Rubya Pereira ZaccaronLaboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Brazil.
Camila da CostaLaboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Brazil.
João Vitor Silvano BittencourtLaboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Brazil.
Henrique Borba ModolonBiomaterials and Nanostructured Materials Group, Postgraduate Program in Materials Science and Engineering (PPGCEM), Universidade do Extremo Sul Catarinense, Criciúma, Brazil.
Adrielly Vargas LidioLaboratory of Experimental Neurology in the Line of Research in Neurodegenerative Diseases of the Postgraduate Program in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Brazil.
Sabrina ArcaroBiomaterials and Nanostructured Materials Group, Postgraduate Program in Materials Science and Engineering (PPGCEM), Universidade do Extremo Sul Catarinense, Criciúma, Brazil.
Josiane BudniLaboratory of Experimental Neurology in the Line of Research in Neurodegenerative Diseases of the Postgraduate Program in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Brazil.
Yaodong GuFaculty of Sports Science, Ningbo University, Ningbo, China.
Anand ThirupathiFaculty of Sports Science, Ningbo University, Ningbo, China.
Paulo Cesar Lock SilveiraFaculty of Sports Science, Ningbo University, Ningbo, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder that requires innovative therapeutic strategies. This is the first study to evaluate the synergistic effects of LIPUS and CUR-AuNPs in an AD model, which aimed to investigate the effects of these therapies on learning, memory and neuroinflammation in mice with

Indexed as

Alzheimer DiseaseCurcuminGoldMetal NanoparticlesAmyloid beta-PeptidesAnimalsBlood-Brain BarrierDisease Models, AnimalHippocampusMaleMaze LearningMicePeptide FragmentsUltrasonic WavesAmyloid beta-PeptidesCurcuminGoldPeptide FragmentsAlzheimer's diseaseLIPUSnanotechnologyNeurodegenerative diseaseneuroinflammation

Identifiers

PMID41277070
PMCPMC12646100

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.