Evidence map›Paper›PMID 41277055›Full record

ArticleAngewandte Chemie (International ed. in English)2026

Ribosomal Synthesis of Topologically Defined Thioisoindole-Bridged Bicyclic Peptides.

Yue Zhang, Alexander A Vinogradov, Yin Sun, Hiroaki Suga

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yue ZhangDepartment of Chemistry, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan.ORCID 0000-0001-6807-2084
Alexander A VinogradovDepartment of Chemistry, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan.ORCID 0000-0002-8899-0533
Yin SunDepartment of Chemistry, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan.
Hiroaki SugaDepartment of Chemistry, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, 113-0033, Japan.ORCID 0000-0002-5298-9186

Funding

Japan Society for the Promotion of Science (JSPS, International Research Fellow) Grant-in-Aid for Scientific Research 22F22334Japan Society for the Promotion of Science (JSPS, International Research Fellow) Grant-in-Aid for Scientific Research 22KF0114NUS Presidential Young Professor A-0010082-00-00NUS Presidential Young Professor A-0010082-01-00Specially Promoted Research JP20H05618
6 · The paper itself

Abstract

Macrocyclic peptides are promising scaffolds for drug discovery due to their structural rigidity and high target specificity. Here, we report a strategy for in vitro ribosomal translation of thioisoindole-bridged bicyclic peptides. Central to this approach is a newly developed flexizyme substrate, Ac-Ala(NtBA)

Indexed as

Peptides, CyclicRibosomesPeptides, CyclicBicyclic peptidesIn vitro translationPeptidePeptide crosslinkingRibosomal peptide synthesis

Identifiers

PMID41277055
PMCPMC12790353

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.