ArticleChemistry (Weinheim an der Bergstrasse, Germany)2025
Enhancing G-Quadruplex Binding: Rational Design and Biophysical Evaluation of Dimeric Ligands.
Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Detangling knots: the intricate roles of G-quadruplexes in herpesvirus replication.Journal of virology · 2026Review
- RNA G-quadruplex structure recognition by chimeric peptides.Nucleic acids research · 2026Article
- Modulating G-quadruplexes for therapeutic intervention: Structural diversity, stability, and emerging nucleic-acid-based strategies.Molecular therapy. Nucleic acids · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
G-quadruplexes (G4s) are non-canonical nucleic acid structures formed by guanine-rich sequences. Within the human genome, beyond telomeres, G4 motifs have also been found in promoters, implying a potential role in gene regulation that could be achieved through interactions with small-molecule ligands. In this field, anthraquinone represented a privileged scaffold for the design of G4-targeting molecules. Additionally, emerging evidence proved that compounds bearing two aromatic cores can offer enhanced affinity and selectivity toward G4s due to cooperative binding in a tweezer-like fashion. This study reports the rational design and synthesis of anthraquinone-based building blocks conceived to generate a dimeric ligand connected through a flexible polyethylene glycol (PEG) linker to potentially recognize G4 as molecular tweezers. The interaction of the synthesized compounds with G4 structures has been investigated by biophysical techniques, including fluorescence thermal shift assays, electrospray ionization-mass spectrometry and circular dichroism (CD) spectroscopy, supported by molecular modeling studies. Finally, cytotoxicity assays were performed to evaluate the antiproliferative effects of the new ligands.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.