Evidence map›Paper›PMID 41276978›Full record

ArticleActa oncologica (Stockholm, Sweden)2025

Utilisation of healthcare in children born to lymphoma survivors in Sweden.

Joshua P Entrop, Viktor Wintzell, Caroline E Dietrich, Ingrid Glimelius, Tarec C El-Galaly, Karin E Smedby, Sandra Eloranta

Abstract read
In one paragraph

Article in Acta oncologica (Stockholm, Sweden), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joshua P EntropClinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden. joshua.entrop@ki.se.ORCID 0000-0003-1614-8096
Viktor WintzellClinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Caroline E DietrichClinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Ingrid GlimeliusDepartment of Immunology, Genetics and Pathology, Cancer Precision Medicine, Uppsala University, Uppsala, Sweden.
Tarec C El-GalalyClinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; Department of Hematology, Aarhus University Hospital.
Karin E SmedbyClinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of Hematology, Karolinska University Hospital, Stockholm, Sweden.
Sandra ElorantaClinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeAdvances in lymphoma treatment lead to a growing population of lymphoma survivors in childbearing ages who might be concerned about the impact of their disease on their children's health. In this study, we aim to explore healthcare utilisation patterns that were associated with parental history of lymphoma. PATIENTS/MATERIAL AND

methodsChildren born to lymphoma survivors (diagnosed over the period 2000-2018) were identified by linking the Swedish Cancer Register to national population registers. Each child born to a lymphoma survivor was matched on maternal age at childbirth to five children born to lymphoma-free parents. Information on in- and outpatient diagnoses and drug dispensations up to age five were obtained for all children.

resultsWe identified a total of 1,424 children born to lymphoma survivors and 7,120 matched children born to lymphoma-free parents. Children born to lymphoma survivors had a 8% higher healthcare utilisation rate (rate ratio: 1.08, 95% confidence intervals: 1.06-1.10) than other children. The panorama of diseases requiring healthcare utilisation was diverse and only one disease (International Classification of Diseases-10: H66, otitis media, unspecified) and one drug cluster (Anatomical Therapeutic Chemical: J07BC20, combination vaccine against hepatitis A and hepatitis B) was associated with a systematic difference (p < 0.05) when applying tree-based scan statistics.

interpretationChildren born to lymphoma survivors had slightly increased healthcare utilisation during early childhood. However, no strong or consistent disease- or drug-specific clusters explained this increase. Findings therefore suggest that the elevated healthcare use may reflect heightened health-seeking behaviour among cancer survivors, rather than underlying morbidity in their children. These results provide reassurance for lymphoma survivors considering parenthood.

Indexed as

Cancer SurvivorsLymphomaPatient Acceptance of Health CareAdultChildChild, PreschoolFemaleHumansInfantMaleRegistriesSweden

Identifiers

PMID41276978
PMCPMC12659140

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.