ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Macrophagic Sclerostin Loop2-ApoER2 Interaction Required by Sclerostin for Cardiovascular Protective Action.
Abstract read
In one paragraph
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Immunomodulatory effects of ultrasonically lysed Bifidobacterium breve on Pam3CSK4-stimulated J774A.1 macrophages via SIRT1/NRF2 activation and NF-κB suppression.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Macrophagic Sclerostin Loop2-ApoER2 Interaction Required by Sclerostin for Cardiovascular Protective Action.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Combined Targeted Drug Delivery Systems for Mineral Metabolism Disorders in Chronic Kidney Disease: A Narrative Review.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Luyao WangLaw Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases (TMBJ), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, 000000, China.ORCID https://orcid.org/0000-0002-2403-8156
Xiaohui TaoLaw Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases (TMBJ), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, 000000, China.
Ning ZhangSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, 000000, China.
Xin YangLaw Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases (TMBJ), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, 000000, China.
Hewen JiangSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, 000000, China.
Xiaofei LiLaw Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases (TMBJ), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, 000000, China.
Shenghang WangLaw Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases (TMBJ), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, 000000, China.
Shijian DingLaw Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases (TMBJ), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, 000000, China.
Sifan YuLaw Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases (TMBJ), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, 000000, China.
Huarui ZhangSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, 000000, China.
Yihao ZhangSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, 000000, China.
Nanxi LiLaw Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases (TMBJ), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, 000000, China.
Haitian LiLaw Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases (TMBJ), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, 000000, China.
Zhanghao LiLaw Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases (TMBJ), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, 000000, China.
Xiaoxin WenLaw Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases (TMBJ), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, 000000, China.
Meiheng SunLaw Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases (TMBJ), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, 000000, China.
Chuanxin ZhongLaw Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases (TMBJ), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, 000000, China.
Jin LiuLaw Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases (TMBJ), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, 000000, China.
Yuanyuan YuLaw Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases (TMBJ), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, 000000, China.
Xianghang LuoXiangya Hospital of Central South University, Hunan, 410008, China.
Tao ZhangShanghai Institute of Technical Physics Chinese Academy of Sciences, Shanghai, 200083, China.
Shu ZhangThe Key Laboratory of Aerospace Medicine, Ministry of Education, Air Force Medical University, Xi'an, Shanxi, 710000, China.
Péter FerdinandyDepartment of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, 1007, Hungary.
Yu HuangBiomedical Sciences and Vascular Biology, City University of Hong Kong, Hong Kong SAR, 000000, China.
Daqing MaPerioperative and Systems Medicine Laboratory and Department of Anesthesiology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Centre for Child Health, Hangzhou, 242332, China.
Aiping LuLaw Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases (TMBJ), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, 000000, China.
Baoting ZhangSchool of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, 000000, China.
Ge ZhangLaw Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases (TMBJ), School of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, 000000, China.ORCID https://orcid.org/0000-0002-7807-7695
Funding
Inter-institutional Collaborative Research Scheme from Hong Kong Baptist University RC-ICRS/19-20/01Key Project of Research and Development Plan of Hunan Province 2022WK2010National Key R&D Program from the Ministry of Science and Technology of China 2018YFA0800804National Natural Science Foundation of China 82300988Research Grants Council of the Hong Kong Special Administrative Region, China 12100725Research Grants Council of the Hong Kong Special Administrative Region, China 12100921Research Grants Council of the Hong Kong Special Administrative Region, China 12102223Research Grants Council of the Hong Kong Special Administrative Region, China 12102524Shenzhen-Hong Kong-Macau Science and Technology Plan Project SGDX20230821095359002University Grants Committee T12-201/20-RUniversity-Industry Collaboration Programme from Innovation and Technology Commissions of the Hong Kong Special Administrative Region, China UIM/298University-Industry Collaboration Programme from Innovation and Technology Commissions of the Hong Kong Special Administrative Region, China UIM/328
Abstract
Therapeutic antibody against sclerostin loop2 promoted bone formation in postmenopausal osteoporosis but caused severe cardiovascular events in clinical applications. The studies of atherosclerosis and aortic aneurysm in SOST
Indexed as
Adaptor Proteins, Signal TransducingAtherosclerosisLDL-Receptor Related ProteinsMacrophagesAnimalsAortic AneurysmDisease Models, AnimalHumansMiceMice, Inbred C57BLMice, KnockoutAdaptor Proteins, Signal TransducingLDL-Receptor Related Proteinslow density lipoprotein receptor-related protein 8Sost protein, mouseApoER2 (LRP8)cardiovascular eventsmacrophagesclerostin
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.