Evidence map›Paper›PMID 41276898›Full record

ArticleThe Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology2026

Sildenafil suppresses the activation of hypertrophic scar fibroblasts by promoting the KLF15-mediated inhibition of

Caihua Li, Yi Xu, Bin Cao, Ye Fan, Jie Bin, Xiuping Wang, Churuo Zeng

Abstract read
In one paragraph

Article in The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. What KJPP looks for: guidance from initial editorial screening.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Caihua LiPlastic Surgery and Cosmetic Dermatology, The Second People's Hospital of Hunan Province, Brain Hospital of Hunan Province, Changsha 410013, Hunan Province, China.
Yi XuPlastic Surgery and Cosmetic Dermatology, The Second People's Hospital of Hunan Province, Brain Hospital of Hunan Province, Changsha 410013, Hunan Province, China.
Bin CaoOrthopedics and Arthrology, The Second People's Hospital of Hunan Province, Brain Hospital of Hunan Province, Changsha 410013, Hunan Province, China.
Ye FanPathologist, The Second People's Hospital of Hunan Province, Brain Hospital of Hunan Province, Changsha 410013, Hunan Province, China.
Jie BinPlastic Surgery and Cosmetic Dermatology, The Second People's Hospital of Hunan Province, Brain Hospital of Hunan Province, Changsha 410013, Hunan Province, China.
Xiuping WangPlastic Surgery and Cosmetic Dermatology, The Second People's Hospital of Hunan Province, Brain Hospital of Hunan Province, Changsha 410013, Hunan Province, China.
Churuo ZengPlastic Surgery and Cosmetic Dermatology, The Second People's Hospital of Hunan Province, Brain Hospital of Hunan Province, Changsha 410013, Hunan Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypertrophic scarring (HS) is a dermal fibroproliferative disorder accompanied by pain. Sildenafil (SIL) has been shown to have a protective effect against fibrosis. This study aimed to determine the effects and mechanisms of SIL on the proliferation, migration, and extracellular matrix (ECM) production of HS fibroblasts. The expression levels of Krüppel-like factor 15 (KLF15) and lysyl oxidase-like 1 (

Indexed as

Cicatrix, hypertrophicKruppel-like factorProtein-lysine 6-oxidaseSildenafil citrateTransforming growth factor beta

Identifiers

PMID41276898
PMCPMC12954782

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.