Evidence map›Paper›PMID 41276833›Full record

ArticleJournal of nanobiotechnology2025

Cu-doping site regulation in carbon dots for concurrent cuproptosis-like death anti-bacteria and osteogenesis of infected bone defects.

Bo Yuan, Yifan Tang, Lang Yan, Xiongsheng Chen, Bijiang Geng, Yin Zhao, Jianlin Shi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bo Yuan *Department of Orthopedics, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China.
Yifan Tang *Department of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, China.
Lang Yan *Department of Health Toxicology, Faculty of Naval Medicine, Naval Medical University, Shanghai, 200433, China.
Xiongsheng ChenDepartment of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, China. chenxiongsheng@vip.sohu.com.
Bijiang GengSchool of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, China. bjgeng1992@shu.edu.cn.
Yin ZhaoDepartment of Orthopedics, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200080, China. moonwalkerxj@126.com.
Jianlin ShiState Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.

Funding

China Postdoctoral Science Foundation 2024M753364Clinical Research Program of Shanghai Municipal Health Commission 202340075National Natural Science Foundation Incubation Program of Naval Medical University 2022MS034National Natural Science Foundation Incubation Program of Naval Medical University 2023MS034National Natural Science Foundation of China 82302736National Natural Science Foundation of China 82372452National Natural Science Foundation of China 82402776
6 · The paper itself

Abstract

Infected bone defect repair suffers frequently from the insufficient bone differentiation activity and the stubborn biofilm formation resulting from bacterial infections. In addition, the incorporation of non-biocompatible antibiotics into scaffolds may not only induce the proliferation of multidrug-resistant bacteria but also hinders the repair of the bone defects. Herein, we present, for the first time, a Cu-doping site regulation strategy in carbon dots (CDs) to boost both antibacterial and osteogenic activities for the repair of infected bone defects. The balanced osteogenic and antibacterial activity enhancements have been achieved by regulating the Cu doping sites: those in the plane rather than at the edge of CDs have endowed the doped CDs with excellent antibacterial activity through a ROS production-mediated cuproptosis-like death mechanism. In contrast, the edge-doped Cu species was found to present a Cu-crosslinked CD assembly (Cu

Indexed as

Anti-Bacterial AgentsCarbonCopperOsteogenesisQuantum DotsAnimalsBiofilmsHumansMiceReactive Oxygen SpeciesAnti-Bacterial AgentsCarbonCopperReactive Oxygen SpeciesAntibacterial activityCarbon dotsCu-doping sitesInfected bone defectsOsteogenic activity

Identifiers

PMID41276833
PMCPMC12752118

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.