ArticleBMC oral health2025
Clinicopathological and prognostic implications of OPMDs in oral squamous cell carcinoma: a 17-Year retrospective cohort study.
Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- The Feasibility of One-Stage Instance Segmentation for Detecting Oral Potentially Malignant Disorders in White-Light Clinical Photographs: A Proof-of-Concept Study.Dentistry journal · 2026Article
- Clinicopathological characteristics and follow-up outcomes of patients with oral potentially malignant disorders: A 7-year observational cohort study.Scientific reports · 2026Observational
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8 authors.
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Abstract
objectivesTo characterize the clinicopathologic features of patients with oral squamous cell carcinoma (OSCC) and evaluate the prognostic significance of the history of oral potentially malignant disorders (OPMDs) in this population. MATERIALS AND
methodsThis retrospective, single-center study enrolled 1140 patients from 2000 to 2017 to explore the clinicopathologic features of OSCC patients. After 2:1 propensity score matching, 129 patients with OPMD history (OPMD group) and 258 patients without OPMD history (non-OPMD group) were analyzed in a cohort study. The primary endpoint was overall survival (OS), while the secondary endpoint included disease-specific survival (DSS).
resultsAmong the 1140 OSCC patients, only 17.0% had a well-documented history of OPMDs. The most common tumor site was the tongue (57.3%), and the majority of patients (85.7%) were over 40 years old. Compared to the non-OPMD group, the OPMD group exhibited significantly lower T and N stages, better differentiation, less frequent neck dissection, and shorter hospital stays. However, there were no significant differences in 5-year OS or DSS between the two groups.
conclusionMost OSCC patients lacked a defined history of OPMDs, which may reflect rapid malignant progression of oral lesions. These findings underscore the importance of enhanced vigilance and early diagnostic interventions for OPMDs and OSCC, particularly in individuals over 40 years of age. CLINICAL TRIAL NUMBER: ChiCTR2200065588, Registration Date: 09 Nov. 2022.
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