Trial reportJournal of natural medicines2026
Effect of pre- and postprandial administration of Maoto extract granules on the pharmacokinetics of ephedrine and pseudoephedrine in healthy adults.
Trial report in Journal of natural medicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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0 citing papers in PubMed.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kampo medicines are widely co-prescribed with Western drugs, yet package inserts typically recommend preprandial dosing. This convention can complicate co-medication schedules and may reduce adherence, while human pharmacokinetic (PK) evidence on meal-timing effects remains limited. We compared pre- versus postprandial administration of maoto to quantify effects on absorption rate and extent for ephedrine and pseudoephedrine. In a two-period, two-sequence crossover, eight healthy adults received ethical maoto extract granules (2.5 g) 30 min before or after a standardized meal. Plasma ephedrine and pseudoephedrine were measured by LC-MS/MS through 24 h. PK was characterized by non-compartmental analysis (NCA) and a pre-specified one-compartment absorption model. The absorption rate constant (k
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Registered trials
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