ArticleProbiotics and antimicrobial proteins2026
Ameliorative Potential of a Lactobacillus Based Probiotic Consortium Against Hepatotoxicity Induced by Combinatorial Exposure to Multiple Heavy Metals.
Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Neurotoxic mechanisms of cadmium in neurodegenerative diseases.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heavy metal exposure remains a serious public health concern due to its cumulative, persistent toxicity and strong affinity for vital organs such as the liver. To mimic real-world scenarios, this study developed a murine model of chronic multi-metal toxicity using low- and high-dose mixtures of arsenic (As), cadmium (Cd), lead (Pb), mercury (Hg), and chromium (Cr). Metal exposure resulted in significant hepatic damage, evidenced by elevated serum transaminases (ALT, AST), increased malondialdehyde (MDA), suppressed antioxidant enzymes (SOD, CAT) including non enzymatic enzyme GSH and a shift toward pro-inflammatory cytokines (TNF-α, IL-6, NF-κB), alongside reduced anti-inflammatory IL-10 levels. Histological assessment revealed hepatocellular necrosis, vacuolation, and inflammatory infiltration. Additionally, increased hepatic metal accumulation and DNA damage (via comet assay) further confirmed systemic toxicity. Hematological analysis showed anemia and leukocytosis in exposed mice. A probiotic cocktail was evaluated for its protective efficacy. Notably, co-administration of the probiotic formulation containing Lactobacillus plantarum (MTCC 2941) and Lactobacillus fermentum (MTCC 903) in metal exposed mice caused significantly improvement in above toxicological manifestations. Altered liver function biomarkers improved, oxidative stress and inflammation were reduced, and antioxidant defense was restored. Probiotic treatment also lowered hepatic metal levels and minimized genotoxic damage, as well as corrected hematological imbalances. These findings suggest that the Lactobacillus-based probiotic consortium offers a multifaceted defense against heavy metal-induced hepatotoxicity, likely through antioxidant activity, immune modulation, and metal detoxification. This study supports the therapeutic potential of targeted probiotics as a safe, dietary approach to mitigate chronic environmental metal exposure.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.