Evidence map›Paper›PMID 41276745›Full record

ReviewProbiotics and antimicrobial proteins2026

Advances in Biological Functions and Applications of Feeding Microorganism-derived Extracellular Vesicles.

Yuanyuan Zhu, Xiaofang Zhang, Xin Feng, Yanyan Huang, Langhong Wang, Huihua Zhang, Xinan Zeng, Zhonglin Tang, Qien Qi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuanyuan ZhuSchool of Animal Science and Technology, Foshan University, Foshan, 528225, China.
Xiaofang ZhangSchool of Animal Science and Technology, Foshan University, Foshan, 528225, China.
Xin FengSchool of Animal Science and Technology, Foshan University, Foshan, 528225, China.
Yanyan HuangGuangdong Provincial Key Laboratory of Intelligent Food Manufacturing, College of Food Science and Engineering, Foshan University, Foshan, 528225, China.
Langhong WangGuangdong Provincial Key Laboratory of Intelligent Food Manufacturing, College of Food Science and Engineering, Foshan University, Foshan, 528225, China.
Huihua ZhangSchool of Animal Science and Technology, Foshan University, Foshan, 528225, China.
Xinan ZengGuangdong Provincial Key Laboratory of Intelligent Food Manufacturing, College of Food Science and Engineering, Foshan University, Foshan, 528225, China.
Zhonglin TangKunpeng Institute of Modern Agriculture at Foshan, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Foshan, 528226, China.
Qien QiSchool of Animal Science and Technology, Foshan University, Foshan, 528225, China. qiqien@fosu.edu.cn.

Funding

Guangdong Province Poultry Industry System Project 2024CXTD20Guangdong Provincial Key Research and Development Program 2023B0202040002
6 · The paper itself

Abstract

Feeding microorganism-derived extracellular vesicles (FMEVs), secreted by probiotic strains authorized in China's Catalogue of Feed Additive Varieties, are emerging as key mediators of microbial benefits in livestock. These nanoscale, bilayer-bound vesicles carry diverse bioactive cargo and have been shown to modulate gut microbiota, enhance epithelial barrier integrity, regulate immune signaling, and support metabolic homeostasis. Their structural stability, strain specificity, and natural capacity for biomolecule delivery underscore their potential as next-generation postbiotics. This review systematically summarizes current knowledge on the biogenesis, molecular composition, and functional mechanisms of FMEVs. Moreover, we evaluate their translational prospects as feed additives, with emphasis on challenges in large-scale production, quality control, and standardization. Finally, we highlight unresolved research questions and outline future directions to facilitate the application of FMEVs in sustainable animal production.

Indexed as

Animal FeedBacteriaExtracellular VesiclesProbioticsAnimalsGastrointestinal MicrobiomeLivestockExtracellular vesiclesFeeding microorganismImmune modulationLivestock healthPostbiotics

Identifiers

PMID41276745

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.