Evidence map›Paper›PMID 41276736›Full record

ArticleOral and maxillofacial surgery2025

Association between bone turnover markers and alveolar socket healing rate: A cross-sectional study.

Ryutaro Nakagaki, Yusuke Kondo, Kiyoshi Shimada, Hiroki Tsukamoto, Tomotaka Nodai, Takashi Munemasa, Taro Mukaibo, Ryuji Hosokawa, Chihiro Masaki

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Article in Oral and maxillofacial surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Ryutaro NakagakiDivision of Oral Reconstruction and Prosthodontics, Kyushu Dental University, 2-6- 1, Manazuru, Kokurakita-ku, Kitakyushu, 803-8580, Japan.
Yusuke KondoDivision of Oral Reconstruction and Prosthodontics, Kyushu Dental University, 2-6- 1, Manazuru, Kokurakita-ku, Kitakyushu, 803-8580, Japan. r07kondo@fa.kyu-dent.ac.jp.
Kiyoshi ShimadaDivision of Oral Reconstruction and Prosthodontics, Kyushu Dental University, 2-6- 1, Manazuru, Kokurakita-ku, Kitakyushu, 803-8580, Japan.
Hiroki TsukamotoDivision of Oral Reconstruction and Prosthodontics, Kyushu Dental University, 2-6- 1, Manazuru, Kokurakita-ku, Kitakyushu, 803-8580, Japan.
Tomotaka NodaiDivision of Oral Reconstruction and Prosthodontics, Kyushu Dental University, 2-6- 1, Manazuru, Kokurakita-ku, Kitakyushu, 803-8580, Japan.
Takashi MunemasaDivision of Oral Reconstruction and Prosthodontics, Kyushu Dental University, 2-6- 1, Manazuru, Kokurakita-ku, Kitakyushu, 803-8580, Japan.
Taro MukaiboDivision of Oral Reconstruction and Prosthodontics, Kyushu Dental University, 2-6- 1, Manazuru, Kokurakita-ku, Kitakyushu, 803-8580, Japan.
Ryuji HosokawaDivision of Oral Reconstruction and Prosthodontics, Kyushu Dental University, 2-6- 1, Manazuru, Kokurakita-ku, Kitakyushu, 803-8580, Japan.
Chihiro MasakiDivision of Oral Reconstruction and Prosthodontics, Kyushu Dental University, 2-6- 1, Manazuru, Kokurakita-ku, Kitakyushu, 803-8580, Japan.

Funding

Japanese Dental Science Federation JDSF-FPC1-2022-05
6 · The paper itself

Abstract

objectivesThis study aimed to examine the relationship between bone turnover markers (BTMs) and alveolar socket healing rate, and determine if bone turnover markers may be applied to implant treatment.

methodsThe study included 21 patients (9 men and 12 women; average age, 61.1 ± 9.8 years) who were scheduled to undergo implant treatment after maxillary or mandibular molar extractions. Alveolar bone density was measured immediately after extraction, 2 months later, and 6 months later using the AI-equipped image analysis system. The healing rate was calculated by dividing the change in bone density by the number of days passed. The following bone turnover markers were measured: procollagen type I N-terminal propeptide (P1NP), bone alkaline phosphatase (BAP), bone resorption markers I collagen cross-linked N-telopeptide (NTx), and tartrate-resistant acid phosphatase 5b (TRACP-5b).

resultsThe alveolar socket healing rate over 6 months did not significantly correlate with each BTM. However, P1NP and NTx did show a significant positive association, while TRACP-5b showed a positive association tendency during the first 2 months following extraction.

conclusionThe bone formation marker (P1NP) and bone resorption markers (NTx and TRACP-5b) were associated with the alveolar socket healing rate in the initial months after extraction. This finding suggests that the early period of alveolar socket healing after extraction might be faster in individuals with a high bone turnover.

Indexed as

Bone RemodelingTooth ExtractionTooth SocketWound HealingAgedAlkaline PhosphataseBiomarkersBone DensityCollagen Type ICross-Sectional StudiesFemaleHumansMaleMiddle AgedMolarPeptide FragmentsAlkaline PhosphataseBiomarkersCollagen Type Icollagen type I trimeric cross-linked peptidePeptide FragmentsPeptidesProcollagenprocollagen Type I N-terminal peptideTartrate-Resistant Acid PhosphataseAlveolar bone densityAlveolar socket healingBone turnover markers

Identifiers

PMID41276736

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.