Evidence map›Paper›PMID 41276724›Full record

ReviewMolecular neurobiology2025

Antimicrobial Resistance and the Blood-Brain Barrier: Complex Interactions and Implications for Neurological Health.

Yuliya Semenova, Maryam Dadar, Larissa Makalkina, Lisa Lim, Geir Bjørklund

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yuliya SemenovaNazarbayev University, Astana, Kazakhstan.
Maryam DadarCONEM International Microbiology Research Group, Paris, France.
Larissa MakalkinaAstana Medical University, Astana, Kazakhstan.
Lisa LimNazarbayev University, Astana, Kazakhstan.
Geir BjørklundCouncil for Nutritional and Environmental Medicine (CONEM), Toften 24, 8610, Mo I Rana, Norway. bjorklund@conem.org.

Funding

Nazarbayev University OPCRP2024008
6 · The paper itself

Abstract

This review explores the interplay between antimicrobial resistance (AMR) and the blood-brain barrier (BBB) and its potential implications for neurological health. It encompasses diverse facets, from the mechanisms used by pathogens to cross the BBB to the clinical outcomes and long-term consequences of compromised BBB integrity. The analysis underscores the complexity of this relationship, revealing how AMR challenges treatment efficacy while the BBB acts as a crucial guardian of central nervous system (CNS) homeostasis. Both direct and indirect mechanisms exist through which pathogens impact the BBB, including structural compromise and the elicitation of neuroinflammatory responses. These interactions have profound implications for the incidence, severity, and prognosis of CNS infections. A novel contribution of this review is its discussion of emerging evidence linking AMR to neurodegenerative processes, as well as its consideration of advanced diagnostic and therapeutic strategies.

Indexed as

Anti-Infective AgentsBlood-Brain BarrierDrug Resistance, MicrobialAnimalsHumansAnti-Infective AgentsAntimicrobial resistanceAntimicrobialsBlood–brain barrierCentral nervous systemNeuroinflammationNeurological healthPathogens

Identifiers

PMID41276724

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.