ArticleMolecular neurobiology2025
Study on the Mechanism of Acanthopanax senticosus Extract Intervening in the Regulation of Parkinson's Disease by BV2 Microglial Cell-Derived Exosomes.
Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease. With the intensification of population aging, its incidence rate continues to rise. Microglia play a significant role in regulating neuronal functions. As carriers of intercellular communication, exosomes can mediate intercellular information transmission and signal regulation. This study aimed to explore the molecular mechanism by which Acanthopanax senticosus extract (AS) interferes with the PD process by regulating BV2 microglial cells exosome communication. A PD-related inflammation model was established by inducing BV2 microglial cells activation with lipopolysaccharide (LPS). Exosomes derived from microglia were isolated by ultracentrifugation. The exosomes were co-cultured with the SHSY5Y-flag-snca cells to detect the expression levels of α-synuclein(α-syn) and tyrosine hydroxylase (TH) in these cells. Transcriptome sequencing using exosomes revealed that the mechanism by which AS treats PD involves the regulation of the long noncoding RNA-microRNA-messenger RNA network in exosomes, and the expression of target genes differentially expressed by exosomes was verified by the RT-qPCR method. This study explored at the molecular level the mechanism by which AS regulates BV2 microglial cells exosomes in intercellular communication therapy for PD, providing new research directions and theoretical basis for finding therapeutic targets for PD.
Indexed as
Identifiers
41276698What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.