SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026
The prognostic value of lymphatic vessel density in squamous cell carcinoma of the tongue: a systematic review and meta-analysis.
Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Lymphatic Endothelial Cells in Health and Disease.MedComm · 2026Review
- Association ofInternational journal of medical sciences · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSquamous cell carcinoma of the tongue (TSCC) is the most common cancer of the oral cavity accounting for 25-40% of the cases. Its unfavorable prognosis is partly attributed to the high incidence of lymph node metastasis, while lymphatic vessel density (LVD) is a potential predictor of tumor progression, metastasis, and patient survival. The purpose of this study was to conduct a systematic review and meta-analysis, that evaluates the prognostic significance of LVD regarding nodal metastasis in TSCC, focusing on intratumoral and peritumoral LVD.
methodsThe studies included referred to patients with TSCC who underwent tumor resection and LVD was estimated via immunohistochemistry (D2-40, LYVE-1). Literature search and data extraction were performed by two independent reviewers. Hazard ratios (HRs) and mean differences were calculated using fixed-effects or random-effects models and heterogeneity was assessed via I² statistics. A total of 26 studies were identified, with 6 meeting eligibility criteria.
resultsThe principal outcome was the significant association between high overall LVD and increased nodal metastasis (summary mean difference: 0.85; 95% CI: 0.21, 1.49; p= 0.010, I²=77.6%). No statistically significant association was observed for intratumoral (summary HR: 0.23; 95% CI: -0.45, 0.92; p = 0.501, I²=81%) or peritumoral LVD (summary HR: 0.10; 95% CI: -0.80, 0.99; p = 0.832, I²=89.8%).
conclusionThe major conclusion of this study is that overall LVD is an indicator of aggressiveness of TSCC and a negative prognostic factor strongly associated with nodal metastasis. LVD assessment can improve risk stratification and lead to personalized treatment approaches in TSCC management.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.