SynthesisEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026
Survival behavior of patients treated with curative and palliative electrochemotherapy for oral and oropharyngeal cancer: a systematic review.
Synthesis in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Two-year follow-up outcomes of neoadjuvant therapy in oral squamous cell carcinoma: an exploratory systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Nutritional management and oral health-related outcomes in head and neck cancer treated with radiotherapy or chemoradiotherapy: a systematic review.BMC oral health · 2026Pooled it
- Transoral Robotic Surgery (TORS) versus radical radiotherapy following neoadjuvant therapy for oropharyngeal carcinoma: a multicenter, real-world efficacy and safety analysis.Journal of robotic surgery · 2026Article
- Inpatient morbidity and structural care burden in oropharyngeal carcinoma in Germany: a nationwide cross-institutional EHR analysis using an AI-enabled data network.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Feasibility and role of the lateral arm free flap following pull-through oropharyngectomy for tonsillar carcinoma: a clinical analysis.BMC surgery · 2026Article
- Long-term survival in a case report with metachronous quadruple primary malignancies involving multiple organ systems.Discover oncology · 2026Article
- Successful prevention of carotid artery rupture by placing a covered stent before salvage resection of advanced recurrent tongue cancer: a case report.BMC surgery · 2026Article
- Efficacy and Safety of Celecoxib Combined with Gabapentin for Head and Facial Pain in Nasopharyngeal Carcinoma: A Retrospective Cohort Study.Journal of pain research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe primary objective of this review is to assess the survival outcomes of patients affected by oral cavity and oropharyngeal squamous cell carcinoma (SCC) treated with electrochemotherapy (ECT). Secondarily, the authors aim to quantify these outcomes according to treatment intent (curative versus palliative) and to evaluate potential prognostic factors influencing survival.
methodsA systematic literature review was conducted in accordance with the PRISMA 2020 guidelines. A comprehensive search was carried out in Embase, PubMed, Scopus, and the Cochrane Library databases to identify studies published between January 1998 and April 2025.
resultsSixteen studies comprising a total of 120 patients were analysed. Overall, ECT was generally well tolerated, with acceptable and manageable adverse events. In the curative-intent cohort, a complete response was achieved in 74% of cases, with a recurrence rate of 12%. One- and two-year disease-free survival (DFS) rates were 94.8% and 77.5%, respectively. Prognostic factors associated with improved survival included early tumor stage, use of adjuvant therapy, and tumors located in the anterior oral cavity. In the palliative-intent cohort, a partial or complete response was observed in 74% of patients, with a one-year DFS of 29.3%. Negative prognostic factors included recurrent disease, prior treatments, and the presence of distant metastases.
conclusionsECT appears to be a promising therapeutic strategy for selected patients with oral cavity and oropharyngeal SCC, particularly in early-stage, treatment-naïve cases. Accurate prognostic stratification is essential to optimize patient selection and improve clinical outcomes.
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Registered trials
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