Evidence map›Paper›PMID 41276657›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026

Primary central nervous system lymphoma mimicking an otitis media complication: an unusual presentation with sigmoid sinus thrombosis.

Nuray Ensari, Ferhan Biten, Erdem Atalay Çetinkaya, Elif Sarıönder Gencer, Yasemin Biçer Gömceli, Ramazan Uyar, Özer Erdem Gür

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Nuray EnsariDepartment of Otorhinolaryngology, University of Health Sciences, Antalya Training and Research Hospital, Antalya, Türkiye, Turkey. nurayakmese@yahoo.com.ORCID http://orcid.org/0000-0002-3373-9173
Ferhan BitenDepartment of Otorhinolaryngology, University of Health Sciences, Antalya Training and Research Hospital, Antalya, Türkiye, Turkey.
Erdem Atalay ÇetinkayaDepartment of Otorhinolaryngology, University of Health Sciences, Antalya Training and Research Hospital, Antalya, Türkiye, Turkey.
Elif Sarıönder GencerDepartment of Neurology, Memorial Antalya Hospital, Antalya, Türkiye.
Yasemin Biçer GömceliDepartment of Neurology, Memorial Antalya Hospital, Antalya, Türkiye.
Ramazan UyarDepartment of Neurosurgery, Medical Park Antalya Hospital, Antalya, Türkiye.
Özer Erdem GürDepartment of Otorhinolaryngology, University of Health Sciences, Antalya Training and Research Hospital, Antalya, Türkiye, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrimary central nervous system lymphoma (PCNSL) rarely presents with isolated otologic symptoms, and such cases are frequently misdiagnosed as infectious complications. We present a unique case of PCNSL initially manifesting as sigmoid sinus thrombosis.

methodsA 70-year-old male presented with right ear pain and hearing loss. Initial imaging demonstrated sigmoid sinus thrombosis, and empirical treatment for presumed otitis media complication was initiated. The patient's clinical course, advanced neuroimaging, and histopathological findings were analyzed.

resultsDespite targeted medical therapy, the patient's symptoms persisted. Repeat neuroimaging revealed an infiltrative lesion involving the temporal bone and posterior fossa. Histopathological analysis confirmed diffuse large B-cell lymphoma, a subtype of PCNSL. The patient commenced systemic chemotherapy with ongoing clinical follow-up.

conclusionThis case underscores the importance of considering malignancy in patients with persistent otologic symptoms unresponsive to optimal therapy. The overlap between benign and malignant middle ear pathologies can obscure early diagnosis. Prompt recognition, comprehensive imaging, and multidisciplinary management are crucial to improving prognosis and survival in atypical PCNSL presentations.

Indexed as

Central Nervous System NeoplasmsLymphoma, Large B-Cell, DiffuseOtitis MediaSinus Thrombosis, IntracranialAgedDiagnosis, DifferentialHumansMagnetic Resonance ImagingMaleTomography, X-Ray ComputedCentral nervous system lymphomaOtitis mediaSigmoid sinus thrombosis

Identifiers

PMID41276657

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