Evidence map›Paper›PMID 41276651›Full record

ArticleHeart and vessels2026

Relationship between epicardial adipose tissue and left atrial stiffness estimated from echocardiographic parameters and left atrial pressure in patients with atrial fibrillation.

Hikaru Hagiwara, Kohei Ouchi, Mana Suzuki, Yumi Iwabuchi, Takashi Okada, Takuro Okamoto, Jiro Koya, Hirokazu Komoriyama, Yoshiya Kato, Toshihisa Anzai

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Article in Heart and vessels, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Hikaru HagiwaraDepartment of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15 Nishi-7, Kita-ku, Sapporo, 060-8638, Japan. hikaruh731@med.hokudai.ac.jp.ORCID http://orcid.org/0000-0003-0176-542X
Kohei OuchiDepartment of Clinical Laboratory Technology, Kushiro City General Hospital, Kushiro, Japan.
Mana SuzukiDepartment of Clinical Laboratory Technology, Kushiro City General Hospital, Kushiro, Japan.
Yumi IwabuchiDepartment of Clinical Laboratory Technology, Kushiro City General Hospital, Kushiro, Japan.
Takashi OkadaDepartment of Clinical Engineering, Kushiro City General Hospital, Kushiro, Japan.
Takuro OkamotoDepartment of Cardiovascular Medicine, Kushiro City General Hospital, Kushiro, Japan.
Jiro KoyaDepartment of Cardiovascular Medicine, Kushiro City General Hospital, Kushiro, Japan.
Hirokazu KomoriyamaDepartment of Cardiovascular Medicine, Kushiro City General Hospital, Kushiro, Japan.
Yoshiya KatoDepartment of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15 Nishi-7, Kita-ku, Sapporo, 060-8638, Japan.
Toshihisa AnzaiDepartment of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Kita-15 Nishi-7, Kita-ku, Sapporo, 060-8638, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe incidence and progression of atrial fibrillation (AF), the most common type of cardiac arrhythmia, correlate with atrial fibrosis. An increased epicardial adipose tissue (EAT) volume is associated with increased atrial fibrosis. Although the presence and severity of atrial fibrosis have been evaluated through various invasive and noninvasive methods, reports examining the association between EAT volume (EATV) and the left atrial (LA) stiffness index through echocardiography or LA compliance as determined by LA pressure are lacking. Therefore, we investigated the relationship between EAT and the LA stiffness index and directly measured LA pressure in patients undergoing AF ablation.

methodsWe retrospectively examined 165 patients who underwent catheter ablation for AF between December 2022 and March 2025. The EATV was measured using contrast-enhanced computed tomography. The LA stiffness index was calculated as the ratio of the early mitral inflow velocity to the early annular tissue velocity. LA pulse pressure was assessed as the difference between peak and nadir LA pressure.

resultsA weak correlation was observed between the LA-EATV index (LA-EATVI) and the LA stiffness index. No significant correlation was observed between the LA-EATVI and LA pulse pressure.

conclusionsOur study showed a weak correlation between the LA-EATVI and the LA stiffness index, but not with LA pulse pressure in patients with AF. Changes in the LA owing to EAT may need to be evaluated quantitatively and qualitatively.

Indexed as

Adipose TissueAtrial FibrillationAtrial Function, LeftAtrial PressureEchocardiographyHeart AtriaPericardiumAgedCatheter AblationEpicardial Adipose TissueFemaleHumansMaleMiddle AgedRetrospective StudiesAtrial fibrillationAtrial fibrosisEpicardial adipose tissueLeft atrial stiffness

Identifiers

PMID41276651

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.