Evidence map›Paper›PMID 41276642›Full record

ArticleScientific reports2025

A pilot study of re-purposing drugs to treat koalas with chlamydia.

Charlotte Fleming, Hannah Nugent, Susel Loli Quinteros, Bentotage S M Fernando, Joel D A Tyndall, Jonathan K Webb, Valentina S A Mella, Wilhelmina M Huston

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Charlotte Fleming *School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, 2007, Australia.
Hannah Nugent *School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, 2007, Australia.
Susel Loli QuinterosSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, 2007, Australia.
Bentotage S M FernandoSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, 2007, Australia.
Joel D A TyndallSchool of Pharmacy, University of Otago, Dunedin, 9054, New Zealand.
Jonathan K WebbSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, 2007, Australia.
Valentina S A MellaSydney School of Veterinary Science, The University of Sydney, Sydney, NSW, 2006, Australia.
Wilhelmina M HustonFaculty of Science, University of Technology Sydney, Sydney, NSW, 2007, Australia. Wilhelmina.Huston@uts.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The koala (Phascolarctos cinereus) is an endangered species in parts of Australia, in part due to chlamydial infections. Treatment is difficult due to the hepatic metabolism of the koala, and the critical reliance on a gut microbiota for survival. This study aimed to identify new compounds for treatment of Chlamydia infections by screening a drug re-purposing library. Screening was conducted using an in vitro cell culture model prior to in vivo mouse infection model testing of two candidates identified from the in vitro screen. One lead, bisoprolol fumarate, showed an impact on chlamydial infection and burden in vitro and in vivo. Whilst the mechanism of action may not support progressing this lead further, the approach to screening the library and list of candidates may enable identification of other new koala treatments. This study demonstrates the potential to apply drug re-purposing to koala treatment and presents a list of candidates that could be explored further.

Indexed as

Anti-Bacterial AgentsChlamydiaChlamydia InfectionsPhascolarctidaeAnimalsDisease Models, AnimalMicePilot ProjectsAnti-Bacterial AgentsAntibioticFatty acidsInfectionLipid

Identifiers

PMID41276642
PMCPMC12748968

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.