Evidence map›Paper›PMID 41276613›Full record

ArticleMolecular psychiatry2026

Cognitive trajectories of psychosis risk: temporal patterns and association with progression.

TianHong Zhang, LiHua Xu, YanYan Wei, HuiRu Cui, XiaoChen Tang, YingYing Tang, YeGang Hu, Dan Zhang, MingLiang Ju, HaiChun Liu and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

TianHong Zhang *Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, PR China. zhang_tianhong@126.com.ORCID http://orcid.org/0000-0002-5379-7119
LiHua Xu *Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, PR China.
YanYan Wei *Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, PR China.
HuiRu Cui *Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, PR China.
XiaoChen TangShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, PR China.
YingYing TangShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, PR China.
YeGang HuShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, PR China.
Dan ZhangShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, PR China.
MingLiang JuShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, PR China.
HaiChun LiuDepartment of Automation, Shanghai Jiao Tong University, Shanghai, 200240, China.
Qiang HuDepartment of Psychiatry, Wuhu Hospital of Anding Hospital (The Fourth People's Hospital of Wuhu), Wuhu, China.
Jin GaoDepartment of Clinical Psychology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, SD, China.
LingYun ZengDepartment of Psychiatric Rehabilitation, Shenzhen Kangning Hospital, ShenZhen, GD, China.
ZhengHui YiShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, PR China.
ChunBo LiShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, PR China.ORCID http://orcid.org/0009-0000-5029-069X
JiJun WangShanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai Engineering Research Center of Intelligent Psychological Evaluation and Intervention, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 200030, PR China. jijunwang27@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive impairment plays a crucial role in the development from clinical high-risk(CHR) to schizophrenia-spectrum psychosis. Understanding its dynamic change trajectories has significant preventive value. This study aims to comprehensively explore the dynamic cognitive trajectories of clinical high-risk(CHR) individuals over a three-year period, compare the trajectories among CHR individuals who convert to psychosis(CHR-C), those who do not(CHR-NC), and healthy controls(HC). This prospective study was part of the Shanghai At Risk for Psychosis(SHARP)-extended program. CHR participants, from psychological counseling outpatient clinics and medication - naive, were followed up at baseline (T1), 2 months ± 1 week (T2), 1 year ± 1 month (T3), 2 years ± 1 month (T4), and 3 years ± 1 month (T5). All participants completed the Chinese version of the MATRICS Consensus Cognitive Battery(MCCB) at these five strictly fixed time points to assess neurocognitive function. Conversion to psychosis was determined as main outcome. A total of 43 CHR(median age, 16[IQR, 15-18] years; 14 men[32.6%]) and 18 HC(median age, 17[IQR, 16-18] years; 8 men[44.4%]) completed five fixed-time cognitive assessments over three years. During the three-year period, CHR individuals were categorized into CHR-C(n = 19) and CHR-NC(n = 24). CHR-C individuals showed more significant cognitive impairments at all time points compared to CHR-NC and HC. The cognitive decline in CHR-C was most prominent in the first year. Growth curve modeling showed that, compared with the HC group, the CHR-C group had a significant negative impact on the composite score of neurocognition(t = -2.809, p = 0.007), and the effect of time is marginally significant(t = -1.911, p = 0.057). The repeated-measures analysis of variance(RMANOVA) indicated significant differences among groups and time-related changes in cognitive scores. Over the entire period, there were highly significant main effects of Time(F = 15.162, p < 0.001, η

Indexed as

Psychotic DisordersAdolescentAdultChinaCognitionCognitive DysfunctionDisease ProgressionFemaleHumansLongitudinal StudiesMaleNeuropsychological TestsProdromal SymptomsProspective StudiesRisk FactorsSchizophrenia

Identifiers

PMID41276613

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.