Evidence map›Paper›PMID 41276611›Full record

ArticleMolecular psychiatry2026

Individualized cortical thickness asymmetry in autism spectrum disorder and schizophrenia.

Marta Martín Echave, Hugo G Schnack, Covadonga M Díaz-Caneja, Laura Pina-Camacho, Niels Janssen, Pedro M Gordaliza, Kuan H Kho, Elizabeth E L Buimer, Neeltje E M van Haren, Wiepke Cahn and 4 more

Abstract read
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In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Marta Martín Echave *Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.ORCID http://orcid.org/0009-0003-4922-4136
Hugo G Schnack *Department of Psychiatry, UMCU Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Covadonga M Díaz-CanejaDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.ORCID http://orcid.org/0000-0001-8538-3175
Laura Pina-CamachoDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.ORCID http://orcid.org/0000-0003-1960-6443
Niels JanssenDepartment of Psychology, Universidad de la Laguna, Tenerife, Spain.
Pedro M GordalizaCIBM Center for Biomedical Imaging, Lausanne, Switzerland.ORCID http://orcid.org/0000-0001-5305-3104
Kuan H KhoDepartment of Neurosurgery, Medisch Spectrum Twente, Enschede, The Netherlands.ORCID http://orcid.org/0000-0002-1834-0922
Elizabeth E L BuimerDepartment of Psychiatry, UMCU Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Neeltje E M van HarenDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Sophia Children's Hospital, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-3090-7653
Wiepke CahnDepartment of Psychiatry, UMCU Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.
René S KahnDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-5909-8004
Hilleke E Hulshoff PolDepartment of Psychiatry, UMCU Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.
Celso ArangoDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.ORCID http://orcid.org/0000-0003-3382-4754
Joost JanssenDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain. joost.janssen76@gmail.com.ORCID http://orcid.org/0000-0001-7613-2067

Funding

Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III) PI16/02012, PI17/01249, PI17/00997, PI19/01024, PI20/00721, PI22/01824, PI22/01621, PI23/00625
6 · The paper itself

Abstract

Cortical thickness asymmetry has been proposed as a latent biomarker for autism spectrum disorder (ASD) and schizophrenia (SZ). However, the degree of abnormal asymmetry at the individual level in ASD and SZ remains unclear. To investigate this, we employed a normative modeling approach. Normative ranges for the whole brain and regional (160 cortical parcels) cortical thickness asymmetry index (AI) were established using a training set of healthy subjects (n = 4904, 45.15% male, age range: 6-95 years), controlling for age, sex, image quality, and scanner. We calculated z-scores to quantify individual deviations from the normative median in a test set consisting of healthy controls (HC

Indexed as

Autism Spectrum DisorderCerebral CortexSchizophreniaAdolescentAdultAgedAged, 80 and overBrainBrain Cortical ThicknessChildFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedYoung Adult

Identifiers

PMID41276611

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.