ReviewChinese medical journal2026
Role of LINE-1 in the nervous system and neurological disorders.
Review in Chinese medical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- PIWI-piRNA Axis in Epilepsy: Bridging Epigenetic Regulation, Neuroinflammation, and Neuronal Excitability.Molecular neurobiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
abstractLong interspersed nucleotide element-1 (LINE-1) is the only known reverse transcriptional transposon in the human genome with autonomous transposition capabilities. It can replicate and insert itself into new gene sites through the reverse transcription of transposons. The activation of LINE-1 is closely related to the occurrence and development of aging, cancer, and neurological diseases, and therefore has received widespread attention. However, research on LINE-1 in the nervous system is still in its early stages. Emerging evidence suggests that LINE-1 can undergo reverse transcriptional translocation and be regulated in neurons and neuroglial cells, playing a crucial role in neuronal diversity, neural plasticity, and behavioral phenotypes. In this review, we summarize the multifaceted functions of LINE-1 in neuronal function and evolution, synapse formation, and its implications for various neurological conditions, including neurodevelopmental disorders, neurodegenerative diseases, and emotional disorders. In addition, we also discuss the potential role of LINE-1 as a diagnostic biomarker and a therapeutic target in these neurological disorders. A comprehensive understanding of LINE-1's functions in the nervous system will enhance our insight into the pathogenesis of neurological diseases and may aid in the development of new therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.