Evidence map›Paper›PMID 41276491›Full record

ArticleGenes, brain, and behavior2025

Shared Genetic Links Between Birth Weight and Developmental-Behavioral Disorders.

Rongyue Sun, Guosheng Yu, Yanzhao Luo, Shikang Fan, Junhui Yuan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, brain, and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rongyue SunDepartment of Pulmonary and Critical Care Medicine, People's Hospital of Jingning She Autonomous County, Jingning, Zhejiang, PR China.
Guosheng YuDepartment of Pediatrics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, PR China.ORCID 0009-0007-2552-3982
Yanzhao LuoDepartment of Pediatrics, Lishui People's Hospital, Lishui, Zhejiang, PR China.
Shikang FanDepartment of Orthopedics, People's Hospital of Jingning She Autonomous County, Lishui, Zhejiang, PR China.
Junhui YuanDepartment of Pediatrics, Wenling Maternal and Child Health Care Hospital, Wenling, Zhejiang, PR China.ORCID 0009-0000-9992-3486

Funding

Zhejiang Provincial Medicine and Health Plan Project 2022517417
6 · The paper itself

Abstract

While observational studies have linked birth weight to developmental-behavioral disorders, establishing genetic correlations and causal relationships remains challenging due to potential confounding factors. In this study, we assessed genetic correlations between birth weight and developmental-behavioral disorders using linkage disequilibrium score regression (LDSC), identified pleiotropic loci and genes through Pleiotropy Analysis under Composite Null Hypothesis (PLACO), and investigated causal relationships via Mendelian randomization (MR) analysis. The results revealed significant negative genetic correlations between ADHD and birth weight (fetal: r

Indexed as

Attention Deficit Disorder with HyperactivityBirth WeightFemaleGenetic PleiotropyHumansLinkage DisequilibriumMaleMendelian Randomization AnalysisPolymorphism, Single NucleotideQuantitative Trait Locibirth weightdevelopmental‐behavioral disordersgenome‐wide association studyMendelian randomization analysis

Identifiers

PMID41276491
PMCPMC12640763

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.