ArticleJournal of clinical periodontology2026
Preclinical Evaluation of the Effect of Liquid Platelet-Rich Fibrin and a Volume-Stable Collagen Matrix on Periodontal Regeneration.
Article in Journal of clinical periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Preclinical Evaluation of the Effect of Liquid Platelet-Rich Fibrin and a Volume-Stable Collagen Matrix on Periodontal Regeneration.Journal of clinical periodontology · 2026Article
- Growth factor enriched collagen matrix versus de-epithelialized graft in root coverage procedures - A randomized parallel arm clinical trial.Journal of oral biology and craniofacial researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
aimTo evaluate the regenerative potential of liquid platelet-rich fibrin (PRF), with and without a volume-stable collagen matrix (VCMX), in periodontal intrabony defects using histological, histometric and micro-CT analyses. MATERIALS AND
methodsOne-wall intrabony defects were surgically created in six beagle dogs and treated with either VCMX plus liquid PRF (TG1), liquid PRF alone (TG2), VCMX alone (CG1) or left empty (CG2). After 12 weeks, samples were analysed by micro-CT, histology and histometry.
resultsHealing was uneventful in all animals. TG1 showed the greatest cementum (4.08 ± 0.88 mm) and bone formation (3.42 ± 0.70 mm), followed by TG2 (2.92 ± 1.13 mm cementum, 3.19 ± 0.78 mm bone) and CG1 (2.07 ± 1.06 mm cementum, 3.29 ± 0.77 mm bone). CG2 exhibited the poorest outcomes (0.84 ± 0.74 mm cementum, 2.58 ± 0.38 mm bone). Micro-CT confirmed higher bone volume in TG1 and TG2 compared to CG2; however, the difference was not significant. All treatment groups showed significantly greater cementum and bone formation compared to CG2.
conclusionsWithin its limitations, the present study indicates that (i) liquid PRF, alone or combined with a volume-stable collagen matrix, enhances periodontal regeneration more than open flap debridement alone, and (ii) the combination tends to show the most favourable outcomes.
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Registered trials
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